II. Pathophysiology
- Onset 2 to 12 weeks after starting Antiretroviral therapy for HIV (onset up to years after starting CART in rare cases)
- Recovering Immune System and rising CD4 Counts respond to latent infections and malignancies
III. Findings
- Fever
- Lymphadenopathy
- Symptoms or signs related to underlying infection or malignancy
IV. Risk Factors
- Low starting CD4 Count
V. Differential Diagnosis
- Antiretroviral therapy related Drug Reaction
VI. Management
- Treat underlying infection or malignancy
- Observation and supportive care
- Consult with HIV specialist
- In unusual cases, Antiretroviral therapy may need to be held