II. Indications
-
HIV Infection (part of combination therapy)
- Multiresistant HIV in treatment experienced patients
III. Mechanism
- Ibalizumab is a recombinant Monoclonal Antibody inhibiting HIV-1 from infecting CD4+ T Cells
- Post-Attachment Inhibitor
- Binds domain 2 of CD4, inhibiting post-attachment steps needed for HIV entry into host cells
- Blocks cell-cell fusion mediated HIV Transmission
IV. Dosing: Adult
-
General
- Indicated only in multiresistant HIV in treatment experienced patients
- Administer in combination with other Antiretrovirals
- Inject immediately after reconstituting solution
- Arm cephalic veins are preferred IV infusion sites
- Load: 2000 mg IV over 30 minutes (and monitor for 1 hour)
- Maintenance: 800 mg IV over 30 minutes every 14 days
- Monitor for 15 minutes (monitor up to 60 minutes if prior reaction)
- Give loading dose instead, if maintenance dose is delayed >3 days (>17 days from last dose)
V. Adverse Effects
VI. Safety
- Pregnancy
- Unknown safety in pregnancy (registry exists)
- Increased fetal exposure after 20 weeks
VII. Resources
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Related Studies
Definition (NCI) | A humanized monoclonal antibody against CD4, with anti-human immunodeficiency virus (HIV) activity. Ibalizumab binds to CD4, the primary receptor for HIV, thereby inhibiting HIV entry into CD4-positive T-cells. This leads to a reduction in viral load. |
Concepts | Immunologic Factor (T129) , Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | C481504 |
English | Ibalizumab, ibalizumab, TMB-355, TNX-355, Immunoglobulin G4, Anti-(Human CD4 (Antigen)) (Human-Mouse Monoclonal 5A8 Gamma-4-Chain), Disulfide with Human-Mouse Monoclonal 5A8 Kappa-Chain, Dimer, IBALIZUMAB |