II. Mechanism

III. Pharmacokinetics

  1. Converted to Agenerase in vivo

IV. Contraindications

  1. Sulfonamide Allergy (Exercise caution if used)

V. Adverse Effects

  1. See Protease Inhibitor for adverse effects attributed to the class
  2. Perioral Paresthesias
  3. Rash (19%)
    1. Severe in some cases

VI. Drug Interactions

  1. CYP3A4 inhibitor

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