II. Indications
III. Dosing
- Sublingual
- One tab SL
- Repeat in 1/2 hour prn
- Maximum: 3/day or 6/week
- Oral tablets available
- Rectal Suppository (Wigraine)
- One rectally at Headache onset
- May repeat hourly
- Maximum: 2 suppositories per day or 12 per month
- Limit no more than 2 days per week
- May use for Menstrual Migraine
IV. Adverse Effects
-
Nausea, Vomiting
- Use Antiemetic
- Rebound Headache
- Occluded vessel in Overdose
- Overdose levels
- Daily use exceeds 6 mg
- Weekly use exceeds 10 mg
- Potentiated by
- Beta Blockers
- Dopamine
- Fever
- Liver Disease
- Overdose levels
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| Definition (MSH) | A vasoconstrictor found in ergot of Central Europe. It is a serotonin agonist that has been used as an oxytocic agent and in the treatment of MIGRAINE DISORDERS. |
| Definition (NCI) | A naturally occurring ergot alkaloid with vasoconstrictor and analgesic property. Ergotamine selectively binds and activates serotonin (5-HT) 1D receptors located on intracranial blood vessels, including those on arterio-venous anastomoses, thereby resulting in vasoconstriction and reducing the blood flow in cerebral arteries that may lead to relieve of vascular headaches. This agent also selectively binds to alpha-adrenergic receptors, thereby stimulating vascular smooth muscle and causing vasoconstriction in both arteries and veins, which also contributes to the relief of headaches. Furthermore, the activation of 5-HT1D receptors on sensory nerve endings of the trigeminal system results in the inhibition of pro-inflammatory neuropeptide release. |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D004878 |
| SnomedCT | 363568006, 32647002, 395975005 |
| LNC | LP17994-2, MTHU024862 |
| English | Ergotaman-3',6',18-trione, 12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'alpha)-, ergotamines (medication), ergotamines, Ergotamine [Chemical/Ingredient], Ergotamine, Ergotamine product, Ergotamine product (product), ergotamine, ERGOTAMINE, Ergotamine (product), Ergotamine (substance), Ergotamine product (substance) |
| Swedish | Ergotamin |
| Czech | ergotamin |
| Finnish | Ergotamiini |
| Russian | ERGOTAMIN, ЭРГОТАМИН |
| Japanese | エルゴタミン, カフェルゴット, 酒石酸エルゴタミン, 酒石酸エルゴタミン･無水カフェイン, ヘクト･M |
| Croatian | ERGOTAMIN |
| Polish | Ergotamina |
| Spanish | ergotamina, producto (producto), ergotamina, producto, ergotamina (producto), ergotamina (sustancia), ergotamina, Ergotamina |
| French | Ergotamine |
| German | Ergotamin |
| Italian | Ergotammina |
| Portuguese | Ergotamina |
Ontology: Wigraine (C0724401)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| English | Wigraine, wigraine |
