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Ontology:
Chlorzoxazone
(C0008296)
Definition (NCI)
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A benzoxazolone derivative with mild sedative and centrally-acting muscle relaxant activities. Although its exact mechanism of action is unknown, chlorzoxazone (CZ) appears to act at the spinal cord and subcortical levels of the brain to inhibit multisynaptic reflex arcs involved in producing and maintaining muscle spasms. This agent is extensively hydroxylated by cytochrome P450 2E1 (CYP2E1) to 6-hydroxychlorzoxazone (HCZ),11,12 which is subsequently glucuronidated and eliminated renally. Highly selective for CYP2E1, CZ may be used as a selective probe for phenotyping CYP2E1 in humans; the ratio of HCZ-to-CZ plasma concentrations obtained 2 to 4 hours after oral administration of CZ may be used as a phenotypic measure of CYP2E1 enzymatic activity.
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Definition (MSH)
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A centrally acting central muscle relaxant with sedative properties. It is claimed to inhibit muscle spasm by exerting an effect primarily at the level of the spinal cord and subcortical areas of the brain. (From Martindale, The Extra Pharmacopoea, 30th ed, p1202)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D002753
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SnomedCT |
400361007, 44908000 |
LNC |
LP18103-9, MTHU003391 |
English |
Chlorzoxazone, 2(3H)-Benzoxazolone, 5-chloro-, chlorzoxazone, muscle relaxants skeletal chlorzoxazone, chlorzoxazone (medication), Chlorzoxazone [Chemical/Ingredient], CHLORZOXAZONE, chlorzoxozone, Chlorzoxozone, Chlorzoxozone (product), Chlorzoxozone (substance) |
Swedish |
Klorzoxazon
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Czech |
chlorzoxazon
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Finnish |
Klooritsoksatsoni
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Russian |
KHLORZOKSAZON, ХЛОРЗОКСАЗОН |
Japanese |
クロルゾキサゾン
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Spanish |
clorzoxozona (producto), clorzoxazona (producto), clorzoxazona, clorzoxozona (sustancia), clorzoxozona, Clorzoxazona |
Polish |
Chlorzoksazon
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French |
Chlorzoxazone
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German |
Chlorzoxazon
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Italian |
Clorozossazone
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Portuguese |
Clorzoxazona
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Ontology:
Methocarbamol
(C0025659)
Definition (NCI)
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A carbamate with centrally acting muscle relaxant properties. Though the exact mechanism of action of methocarbamol was not established, it's postulated to be via a mechanism similar of carbamate, inhibition of acetylcholinesterase at synapses in the autonomic nervous system, neuromuscular junction, and central nervous system. Methocarbamol has no direct effect on the contractile mechanism of striated muscle, the motor end plate or the nerve fiber.
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Definition (MSH)
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A centrally acting muscle relaxant whose mode of action has not been established. It is used as an adjunct in the symptomatic treatment of musculoskeletal conditions associated with painful muscle spasm. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1206)
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D008721
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SnomedCT |
387486000, 83973001 |
LNC |
LP16197-3, MTHU007392 |
English |
Carbamate, Guaiphenesin, Guaiphenesin Carbamate, Methocarbamol, 1,2-Propanediol, 3-(2-methoxyphenoxy)-, 1-carbamate, methocarbamol, methocarbamol (medication), muscle relaxants skeletal methocarbamol, METHOCARBAMOL, Methocarbamol [Chemical/Ingredient], Methocarbamol (product), Methocarbamol (substance) |
Swedish |
Metokarbamol
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Czech |
methokarbamol
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Finnish |
Metokarbamoli
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Russian |
GVAIFENEZINKARBAMAT, METOKARBAMOL, ГВАЙФЕНЕЗИНКАРБАМАТ, МЕТОКАРБАМОЛ |
Japanese |
メトカルバモル, ロバキシン, メトカルバモール, グアイフェネシンカルバメート |
Polish |
Robaksyna, Metokarbamol |
Spanish |
metocarbamol (producto), metocarbamol (sustancia), metocarbamol, Carbamato de Guaifenesina, Metocarbamol |
French |
Méthocarbamol
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German |
Guaiphenesincarbamat, Methocarbamol |
Italian |
Metocarbammolo
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Portuguese |
Carbamato de Guaifenesina, Metocarbamol |
Ontology:
Orphenadrine
(C0029309)
Definition (NCI)
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A muscarinic antagonist with muscle relaxant activity. Although the mechanism of action has not been determined, orphenadrine appears to block muscarinic acetylcholine receptors as well as N-methyl-D-aspartate (NMDA) receptors in the central nervous system (CNS). This may interfere with the transmission of nerve impulses from the spinal cord to the muscles and may help relax muscles. In addition, orphenadrine exerts antagonistic effects on histamine H1 receptors.
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Definition (MSH)
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A muscarinic antagonist used to treat drug-induced parkinsonism and to relieve pain from muscle spasm.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
D009966
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SnomedCT |
35035001, 372714007 |
LNC |
LP15175-0, MTHU002564 |
English |
Methyldiphenylhydramine, Orphenadrine, Ethanamine, N,N-dimethyl-2-((2-methylphenyl)phenylmethoxy)-, orphenadrine (medication), Orphenadrine [Chemical/Ingredient], ORPHENADRINE, orphenadrine, Orphenadrine (product), Orphenadrine (substance) |
Swedish |
Orfenadrin
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Czech |
orfenadrin
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Finnish |
Orfenadriini
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Russian |
ORFENADRIN, METILDIFENILGIDRAMIN, МЕТИЛДИФЕНИЛГИДРАМИН, ОРФЕНАДРИН |
Japanese |
オルフェナドリン, メチルジフェニルヒドラミン |
Polish |
Orfenandryna, Metylodifenylohydramina |
Spanish |
orfenadrina (producto), orfenadrina (sustancia), orfenadrina, Metildifenilhidramina, Orfenadrina |
French |
Orphénadrine
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German |
Methyldiphenylhydramin, Orphenadrin |
Italian |
Orfenadrina
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Portuguese |
Metildifenilidramina, Orfenadrina |
Ontology:
skeletal muscle relaxants
(C0037250)
Concepts |
Pharmacologic Substance
(T121)
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MSH |
D009465
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SnomedCT |
17893001, 372666009 |
English |
Muscle Relaxants, Skeletal, Relaxants, Skeletal Muscle, SKELETAL MUSCLE RELAXANTS, skeletal muscle relaxants (medication), muscle relaxants skeletal, [MS200] SKELETAL MUSCLE RELAXANTS, skeletal muscle relaxant, skeletal muscle relaxants, Skeletal muscle relaxant, Skeletal muscle relaxant (product), Skeletal muscle relaxant (substance), Skeletal muscle tone depressant, Skeletal muscle relaxant, NOS, Skeletal muscle tone depressant, NOS, Skeletal Muscle Relaxants |
French |
Myorelaxants, Décontracturants des muscles striés, Relaxants musculaires, Myorésolutifs, Décontracturants, Décontracturants musculaires, Relaxants des muscles squelettiques |
Czech |
myorelaxancia
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Spanish |
Relajantes del Musculo Esquelético, depresor del tono muscular esquelético, miorrelajante esquelético, relajante de músculo esquelético (sustancia), relajante de músculo esquelético, relajante del músculo esquelético (producto), relajante del músculo esquelético (sustancia), relajante del músculo esquelético |
German |
Skelettmuskelrelaxanzien
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Portuguese |
Relaxantes de Musculo Esquelético
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Italian |
Rilassanti muscolo scheletrici
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Ontology:
metaxalone
(C0163055)
Definition (NCI)
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An oxazolidinone with centrally-acting skeletal muscle relaxant properties. Although the exact mechanism through which metaxalone exerts its effect is largely unknown, it might be due to general central nervous system (CNS) depression. Metaxalone has no direct effect on the contractile mechanisms of striated muscle, the motor end plate, or the nerve fiber.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C011301
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SnomedCT |
87599003, 404863006 |
LNC |
LP100044-9, MTHU035865 |
English |
5-((3,5-dimethylphenoxy)methyl)-2-oxazolidinone, metaxalone, Zorane, 2-Oxazolidinone, 5-((3,5-dimethylphenoxy)methyl)-, metaxalone (medication), muscle relaxants skeletal metaxalone, METAXALONE, metaxalone [Chemical/Ingredient], Metaxalone, Metaxalone (substance), Metaxalone (product) |
Spanish |
metaxalona (sustancia), metaxalona, metaxalona (producto) |