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Definition (NCI_NCI-GLOSS)
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A drug that removes copper from the body and is used to treat diseases in which there is an excess of this metal. It is also being studied as a possible angiogenesis inhibitor in brain tumors.
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Definition (NCI)
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A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. (NCI04)
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Definition (CSP)
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beta dimethyl analog of cysteine; USP lists as a chelating agent.
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Definition (MSH)
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3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.
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Definition (PDQ)
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A beta dimethyl analog of the amino acid cysteine. As a degradation product of penicillin antibiotics, penicillamine chelates with heavy metals and increases their urinary excretion. Possessing antineoplastic properties, penicillamine induces apoptosis by a p53-mediated mechanism and inhibits angiogenesis by chelating with copper, a cofactor for angiogenesis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42546&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42546&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C729" NCI Thesaurus)
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| Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
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| MSH |
D010396
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| SnomedCT |
329465002, 330024005, 387235007, 4219002 |
| English |
beta,beta Dimethylcysteine, beta,beta-Dimethylcysteine, D 3 Mercaptovaline, D Penicillamine, D-3-Mercaptovaline, D-Penicillamine, Dimethylcysteine, Mercaptovaline, Penicillamine, D-Valine, 3-mercapto-, Penicillamine [metabolic], Penicillamine [musculo-skel], Beta-thiovaline, 3-Mercapto-D-valine, Alpha-amino-beta-methyl-beta-mercaptobutyric Acid, Beta,Beta-dimethylcysteine, D-Mercaptovaline, Depamine, Penicillamine [musculoskeletal use], D penicillamine, D-penicillamine (medication), PENICILLAMINE, Penicillamine [Chemical/Ingredient], d penicillamine, d-penicillamine, penicillAMINE, penicillamine, Penicillamine [metabolic] (product), Penicillamine [musculoskeletal use] (product), .beta.,.beta.-Dimethylcysteine, D-3-mercaptovaline, D-penicillamine, beta, beta-Dimethylcysteine, Penicillamine (product), Penicillamine (substance), Penicillamine [metabolic] (substance), Penicillamine [musculoskeletal use] (substance) |
| Swedish |
Penicillamin
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| Czech |
penicilamin
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| Finnish |
Penisillamiini
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| Russian |
MERKAPTOVALIN, PENITSILLAMIN, DIMETILTSISTEIN, ДИМЕТИЛЦИСТЕИН, МЕРКАПТОВАЛИН, ПЕНИЦИЛЛАМИН |
| Japanese |
メルカプトバリン, L-ペニシラミン, ペニシラミン, D-ペニシラミン, β,β-ジメチルシステイン, ベータ,ベータ-ジメチルシステイン, ジメチルシステイン |
| French |
D-Pénicillamine, bêta-Thiovaline, bêta-Mercaptovaline, Diméthylcystéine, Pénicillamine |
| Polish |
Penicylamina, Artamin, Merkaptowalina |
| Spanish |
penicilamina (metabólico), penicilamina (uso musculoesquelético) (producto), penicilamina (metabólico) (producto), penicilamina (uso musculoesquelético), D-3-mercaptovalina, D-penicilamina, beta,beta-dimetilcisteína, penicilamina (producto), penicilamina (sustancia), penicilamina, Mercaptovalina, Penicilamina, Dimetilcisteína, betadimetilcisteína beta |
| German |
Beta,Beta-Dimethylcystein, Dimethylcystein, Mercaptovalin, Penicillamin |
| Italian |
Penicillamina
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| Portuguese |
beta,beta-Dimetilcisteína, Dimetilcisteína, Mercaptovalina, Penicilamina |
