II. Definition
- Less common, milder and superficial form of Pemphigus
III. Signs
- Onset on skin of face in butterfly distribution
- May also involve scalp, chest or upper back
- Rarely involves Oral Mucosa
- Nikolsky's Sign absent
IV. Variants
- Pemphigus erythematosus (Senear-Usher Syndrome)
- Localized variant of Pemphigus Foliaceus
- Associated with Systemic Lupus Erythematosus
- Antinuclear Antibody positive
- Fogo selvagem
- Variant of Pemphigus Foliaceus
- Endemic to Brasil and Colombia
- Associated with chronic Black Fly exposure
- Pemphigus herpetiformis
- Pruritic Blister formation
- May appear similar to Dermatitis Herpetiformis
-
Drug-Induced Pemphigus
- Associated with Penicillamine and Captopril
- Differentiate from Drug-Triggered Pemphigus
- Unmasks Pemphigus Vulgaris
V. Labs: Histology
- Blister forms just below Stratum Corneum of Epidermis
VI. References
- Habif (1996) Clinical Dermatology, Mosby, p. 510
- Cotell (2000) Am J Emerg Med 18(3):288-99 [PubMed]