II. Definition
- Intraepidermal Acantholytic Blister
- Mnemonic: Pemphigus ends in S for Superficial
- Contrast with the deeper Pemphigoid
III. Types: Primary forms of Pemphigus
- Deep Pemphigus (above Basal Cell Layer of Epidermis)
- Pemphigus Vulgaris (most common and most severe)
- Pemphigus Vegetans (rare Pemphigus Vulgaris variant)
- Drug-Triggered Pemphigus (umasks Pemphigus Vulgaris)
- Superficial Pemphigus (involves Stratum Granulosum)
IV. Types: Secondary forms of Pemphigus
V. Signs
- Flaccid Blister (superficial)
-
Nikolsky's Sign
- Positive in Pemphigus Vulgaris
- Negative in Pemphigus Foliaceus (most superficial)
VI. Histology
- All Pemphigus conditions show epidermal Acantholysis
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| Definition (MEDLINEPLUS) |
Pemphigus is an autoimmune disorder. If you have it, your immune system attacks healthy cells in your skin and mouth, causing blisters and sores. No one knows the cause. Pemphigus does not spread from person to person. It does not appear to be inherited. But some people's genes put them more at risk for pemphigus. Pemphigoid is also an autoimmune skin disease. It leads to deep blisters that do not break easily. Pemphigoid is most common in older adults and may be fatal for older, sick patients. Doctors diagnose pemphigus with a physical exam, a biopsy, and blood tests. The treatment of pemphigus and pemphigoid is the same: one or more medicines to control symptoms. These may include
NIH: National Institute of Arthritis and Musculoskeletal and Skin Diseases |
| Definition (NCI) | A blistering skin disorder. Morphologically it is characterized by acantholysis and intraepidermal blister formation. |
| Definition (CSP) | group of chronic blistering diseases characterized histologically by acantholysis and blister formation within the epidermis. |
| Definition (MSH) | Group of chronic blistering diseases characterized histologically by ACANTHOLYSIS and blister formation within the EPIDERMIS. |
| Concepts | Disease or Syndrome (T047) |
| MSH | D010392 |
| ICD9 | 694.4 |
| ICD10 | L10 , L10.9 |
| SnomedCT | 200908008, 156355008, 65172003 |
| English | Pemphigus, PEMPHIGUS, Pemphigus, unspecified, pemphigus, pemphigus (diagnosis), Pemphigus [Disease/Finding], Pemphigus NOS (disorder), Pemphigus (disorder), Pemphigus, NOS, Pemphigus NOS |
| French | PEMPHIGUS, Pemphigus |
| Portuguese | PENFIGO, Pênfigo |
| Japanese | 天疱瘡, ﾃﾝﾎﾟｳｿｳ |
| Swedish | Pemfigus |
| Czech | pemfigus, Pemfigus |
| Finnish | Pemfigus |
| Russian | PEMFIGUS, PUZYRCHATKA, ПЕМФИГУС, ПУЗЫРЧАТКА |
| German | Pemphiguskrankheit, nicht naeher bezeichnet, Pemphiguskrankheiten, Blasensucht, Pemphigus |
| Korean | 상세불명의 천포창, 천포창 |
| Polish | Pęcherzyca |
| Hungarian | Pemphigus |
| Norwegian | Pemfigus |
| Spanish | pénfigo, SAI, pénfigo, SAI (trastorno), pénfigo (trastorno), pénfigo, Pénfigo |
| Dutch | Pemphigus, niet gespecificeerd, pemphigus, Pemphigus |
| Italian | Pemfigo |
