II. Mechanism of Drug-Induced Pemphigus

  1. Sulfhydryl groups lyse disulfide bonds
  2. Results in Blister formation

III. Causes of Drug-Induced Pemphigus

IV. Signs of Drug-Induced Pemphigus

  1. Pemphigus follows medication use of >2 month duration
  2. Similar to Superficial Pemphigus (Pemphigus Foliaceus)
    1. Most cases are mild

V. Differential Diagnosis of Drug-Induced Pemphigus

VI. Course

  1. Drug-Induced Pemphigus
    1. Remits with stopping medication in 40-50% of cases
    2. May follow severe course in some cases
  2. Drug-Triggered Pemphigus
    1. Does not remit
    2. Follows course of Pemphigus Vulgaris

VII. References

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