II. Mechanism of Drug-Induced Pemphigus
- Sulfhydryl groups lyse disulfide bonds
- Results in Blister formation
III. Causes of Drug-Induced Pemphigus
- D-Penicillamine (5% Incidence with Penicillamine)
- Captopril
IV. Signs of Drug-Induced Pemphigus
- Pemphigus follows medication use of >2 month duration
- Similar to Superficial Pemphigus (Pemphigus Foliaceus)
- Most cases are mild
V. Differential Diagnosis of Drug-Induced Pemphigus
- Erythema Multiforme
- Drug-Triggered Pemphigus (unmasks Pemphigus Vulgaris)
VI. Course
- Drug-Induced Pemphigus
- Remits with stopping medication in 40-50% of cases
- May follow severe course in some cases
- Drug-Triggered Pemphigus
- Does not remit
- Follows course of Pemphigus Vulgaris
VII. References
- Habif (1996) Clinical Dermatology, Mosby, p. 512
- Cotell (2000) Am J Emerg Med 18(3):288-99 [PubMed]
- Rye (1997) Am Fam Physician 55(8):2709-18 [PubMed]
Images: Related links to external sites (from Bing)
Related Studies
Concepts | Pathologic Function (T046) |
ICD10 | L10.5 |
SnomedCT | 200907003 |
German | Arzneimittelinduzierter Pemphigus |
Korean | 약물유발성 천포창 |
English | drug-induced pemphigus, pemphigus drug-induced, drug-induced pemphigus (diagnosis), Drug-induced pemphigus, Drug-induced pemphigus (disorder), drug; pemphigus, pemphigus; drug-induced |
Dutch | geneesmiddel; pemphigus, pemphigus; geneesmiddel-geïnduceerd, Door geneesmiddel geïnduceerde pemphigus |
Spanish | pénfigo medicamentoso (trastorno), pénfigo medicamentoso |