II. Indications
- Refractory cutaneous dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Cruris)
- Shorter course (2 instead of 4 weeks) than Clotrimazole
- More convenient (once daily) than other Topical Antifungals
III. Mechanism
- Naphthalenemethylamine derivative
- Benzylamine similar to allylamines (e.g. Terbinafine, Naftifine)
IV. Dosing
- Apply once daily for 14 days to a 2 cm area surrounding Skin Infection
- Note: Unlike other Topical Antifungals, once daily application is sufficient
V. Efficacy
- High tinea cure rates with a 2 week course
- At 4-8 weeks, no significant difference in cure as compared with Clotrimazole
VI. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VII. Resources
- Butenafine Hydrochloride 1% Cream (DailyMed)