II. Indications
- Refractory cutaneous dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Cruris)
- Shorter course (2 instead of 4 weeks) than Clotrimazole
- More convenient (once daily) than other Topical Antifungals
III. Mechanism
- Naphthalenemethylamine derivative
- Benzylamine similar to allylamines (e.g. Terbinafine, Naftifine)
IV. Dosing
- Apply once daily for 14 days to a 2 cm area surrounding Skin Infection
- Note: Unlike other Topical Antifungals, once daily application is sufficient
V. Efficacy
- High tinea cure rates with a 2 week course
- At 4-8 weeks, no significant difference in cure as compared with Clotrimazole
VI. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VII. Resources
- Butenafine Hydrochloride 1% Cream (DailyMed)
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Related Studies
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C067594 |
SnomedCT | 108923003, 373449007 |
English | butenafine, butenafine [Chemical/Ingredient], BUTENAFINE, Butenafine (product), Butenafine (substance), Butenafine |
Spanish | butenafina (producto), butenafina (sustancia), butenafina |
Ontology: Mentax (C0721666)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C067594 |
English | Mentax, butenafine hydrochloride (Mentax), mentax, Bertek brand of butenafine hydrochloride |