II. Indications
III. Contraindications
- Ragweed allergy (relative; may cross-react to Pyrethrins)
IV. Mechanism
- Pyrethrins are Insecticides extracted from chrysanthemums
- Pyrethroids are longer acting derivatives (Permethrin)
- RID is a combination of Pyrethrin and Piperonyl Butoxide
- Piperonyl Butoxide is a synthetic derivative of benzodioxole
- Piperonyl Butoxide is an Insecticide synergist that inhibits Insect microsomal enzyme detoxification activity
- Piperonyl Butoxide is toxic if ingested (Seizures, hepatotoxicity, nephrotoxicity, carcinogenic)
-
Pesticide Agents related to Pyrethrins
- Allethrin
- Cyfluthrin
- Cypermethrin
- Deltamethrin
- Dimethrin
- Fenothrin
- Fenvalerate
- Permethrin
- Remethrin
V. Background
- Advantages
- Available without a prescription
- Convenient (only 10 minute application)
- Disadvantages
- Does not kill all unhatched eggs
- Requires repeat application in 5-7 days
- Treatment failures are common
VI. Medications
- Pyrethrin with Piperonyl Butoxide (RID)
- Shampoo: 60, 120, 240 ml
VII. Dosing: Lice Treatment
VIII. Adverse Effects
- See Pyrethroid Toxicity
- Mechanism
- Nerve toxicity is rare in humans
- Minimal absorption and rapid hepatic metabolism
- Effects
- Allergic Reaction in 1-3%
- Nasal congestion
- Asthma exascerbation
- Topical effects
- Paresthesias (hands and face)
- Rare neurologic effects
- Allergic Reaction in 1-3%
IX. Safety
- Pregnancy Category C
- Unknown safety in Lactation
X. Resources
- Piperonyl Butoxide and Pyrethrum Extract Shampoo (DailyMed)
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Related Studies
Definition (NCI) | A synthetic derivative of benzodioxole and used as an insecticide synergist, Piperonyl Butoxide enhances the active properties of pyrethrin, pyrethroid, rotenone, and carbamate pesticide ingredients by inhibiting insect microsomal enzyme detoxification activity. It is toxic and suspected of causing anorexia, carcinogenesis, convulsions, and dermal irritation, as well as hepatic and renal damage. (NCI04) |
Definition (MSH) | An insecticide synergist, especially for pyrethroids and ROTENONE. |
Concepts | Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131) , Organic Chemical (T109) |
MSH | D010882 |
SnomedCT | 32340007, 412273005 |
English | Butoxide, Piperonyl, Piperonyl Butoxide, 1,3-Benzodioxole, 5-((2-(2-butoxyethoxy)ethoxy)methyl)-6-propyl-, PBO, 5-[[2-(2-Butoxyethoxy)ethoxy]methyl]-6-propyl-1,3-benzodioxole, NCI CO28l3, piperonyl butoxide, Piperonyl Butoxide [Chemical/Ingredient], PIPERONYL BUTOXIDE, Alpha-[2-(2-butoxyethoxy)ethoxy]-4,5-Methylenedioxy-2-Propyltoluene, Piperonyl butoxide, Piperonyl butoxide (substance), Piperonyl butoxide (product), PIPERONYL BUTOXIDE TECHNICAL |
Swedish | Piperonylbutoxid |
Czech | piperonylbutoxid |
Finnish | Piperonyylibutoksidi |
Russian | BUTATSID, PIPERONILBUTOKSID, БУТАЦИД, ПИПЕРОНИЛБУТОКСИД |
Polish | Butotlenek piperonylu |
Spanish | butóxido de piperonilo (sustancia), butóxido de piperonilo, butóxido de piperonilo (producto), Butóxido de Piperonilo |
French | Pipéronyl butoxyde |
German | Piperonylbutoxid |
Italian | Piperonilbutossido |
Portuguese | Butóxido de Piperonila |
Ontology: Pyrethrins (C0034245)
Definition (MSH) | The active insecticidal constituent of CHRYSANTHEMUM CINERARIIFOLIUM flowers. Pyrethrin I is the pyretholone ester of chrysanthemummonocarboxylic acid and pyrethrin II is the pyretholone ester of chrysanthemumdicarboxylic acid monomethyl ester. |
Concepts | Hazardous or Poisonous Substance (T131) , Organic Chemical (T109) |
MSH | D011722 |
SnomedCT | 23178000, 400602009, 45620004 |
English | Pyrethrins, pediculicides pyrethrins, pyrethrins (medication), pyrethrins, Pyrethrins [Chemical/Ingredient], pyrethrin, Pyrethrins (substance), Pyrethrin, Pyrethrin (product), Pyrethrin (substance), Pyrethrins, NOS, PYRETHRINS |
Swedish | Pyretriner |
Czech | pyrethriny |
Finnish | Pyretriinit |
Russian | PIRETRINY, ПИРЕТРИНЫ |
Polish | Pyretryny |
Japanese | ピレスリン, ピレトリン |
French | Pyréthrines |
Spanish | piretrinas (sustancia), piretrinas, piretrina (producto), piretrina (sustancia), piretrina, Piretrinas |
German | Pyrethrine |
Italian | Piretrine |
Portuguese | Piretrinas |
Ontology: RID (C0073361)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C027982 |
English | RID, Rid Pediculicide, rid pediculicide product, rid |
Ontology: Pyrethrum extract (C0347993)
Concepts | Pharmacologic Substance (T121) |
SnomedCT | 256038001, 411383009 |
English | Pyrethrum extract, pyrethrum extract, PYRETHRUM EXTRACT, Pyrethrum Extract, pyrethrum, Pyrethrum, Pyrethrum (substance), Pyrethrum (product) |
Spanish | piretro (sustancia), piretro, piretro (producto) |