Pyrethrin

Aka: Pyrethrin, RID, A-200, Piperonyl butoxide

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II. Background

  1. Extract from chrysanthemums
  2. Pyrethroids are longer acting derivatives (Permethrin)
  3. Pesticide Agents related to Pyrethrins
    1. Allethrin
    2. Cyfluthrin
    3. Cypermethrin
    4. Deltamethrin
    5. Dimethrin
    6. Fenothrin
    7. Fenvalerate
    8. Permethrin
    9. Remethrin

III. Indications

  1. Pediculosis (Lice)

IV. Advantages

  1. Available without a prescription
  2. Convenient (only 10 minute application)

V. Disadvantages

  1. Does not kill all unhatched eggs
  2. Requires repeat application in 5-7 days
  3. Treatment failures are common

VI. Directions for treatment of Lice

  1. Apply Shampoo to involved area
  2. Wash after 10 minutes
  3. Reapply Shampoo in 5-7 days

VII. Preparations

  1. Bottles of 60, 120, 240 ml

VIII. Adverse Effects

  1. Mechanism
    1. Nerve toxicity is rare in humans
    2. Minimal absorption and rapid hepatic metabolism
  2. Effects
    1. Allergic Reaction in 1-3%
      1. Nasal congestion
      2. Asthma exascerbation
    2. Topical effects
      1. Paresthesias (hands and face)
    3. Rare neurologic effects
      1. Seizures
      2. Tremor
      3. Incoordination

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Related Studies

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