III. Indications
- Stubborn periungual warts
- Molluscum Contagiosum in children
IV. Medications
- Background
- Until YCanth was released in 2023, Cantharidin was no longer available is U.S., but available in Canada
- Cantharidin (Cantharone, Canthacur)
- Canthacur PS (w/ Podophyllin 5% + Salicylic Acid 30%)
- Reserve for Plantar Warts due to irritation
- YCanth
- Single use applicator of Cantharidin FDA approved for age >2 years (in 2023, approaches $700/applicator)
- Applied by medical provider every 3 weeks for 4 visits
- Clearance of molluscum in 3 months (NNT 3)
- (2023) Presc Lett 30(10): 58-9
V. Precautions
- Apply ONLY in office
- Avoid touching normal skin
VI. Technique: Cantharidin Application
- Instructions apply to the original Cantharidin
- YCanth has specific instructions (see DailyMed link below)
- Allow liquid to dry over wart
- Then cover with occlusive tape (e.g. Blenderm)
- Remove tape after 24 hours
- Remove earlier for significant discomfort
- In 2-3 days remove Blister under Local Anesthesia
- Snip off near base OR Curette
- Benefits of removing Blister
- Prevents progression to ring wart
- Prevents recurrence
VII. Follow-up
- Consider repeat treatment weekly as tolerated
VIII. Resources
Images: Related links to external sites (from Bing)
Related Studies
Definition (MSHCZE) | Toxická sloučenina, izolovaná ze španělské mušky (Lytta (Cantharis) vesicatoria) a dalšího hmyzu. Je to silný a specifický inhibitor proteinfosfatas 1 (PP1) a 2A (PP2A). Tato sloučenina může vyvolat silné záněty kůže a požitá orálně je extrémně toxická. |
Definition (MSH) | A toxic compound, isolated from the Spanish fly or blistering beetle (Lytta (Cantharis) vesicatoria) and other insects. It is a potent and specific inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). This compound can produce severe skin inflammation, and is extremely toxic if ingested orally. |
Concepts | Pharmacologic Substance (T121) , Hazardous or Poisonous Substance (T131) , Organic Chemical (T109) |
MSH | D002193 |
SnomedCT | 437975006, 86218002 |
English | Cantharidin, Cantharidine, 4,7-Epoxyisobenzofuran-1,3-dione, hexahydro-3a,7a-dimethyl-, (3aalpha,4beta,7beta,7aalpha)-, cantharidin (medication), wart therapeutic agents cantharidin, Cantharidin (product), Cantharidin [Chemical/Ingredient], cantharidine, cantharidin, Cantharidin (substance), CANTHARIDIN |
Swedish | Cantharidin |
Czech | kantharidin |
Finnish | Kantaridiini |
Russian | KANTARIDIN, КАНТАРИДИН |
Japanese | カンタリジン, カンタリス |
Spanish | cantaridina (producto), cantaridina (sustancia), cantaridina, Cantaridina |
Polish | Kantarydyna |
French | Camphre cantharide, Cantharidine |
German | Cantharidin |
Italian | Cantaridina |
Portuguese | Cantaridina |