II. Indications

  1. Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
    1. Other Topical Antifungals are preferred (primarily fungistatic rather than fungicidal)

III. Mechanism

  1. Naphthalene (2 ring Hydrocarbon extracted from Coal Tar) and Thiocarbamate derivative
  2. Primarily fungistatic (as opposed to fungicidal), leaving it less effective at resolution than other Antifungals
    1. Other Topical Antifungals are preferred
  3. Selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase
    1. Inhibits ergosterol synthesis, a key component in fungal cell walls
  4. Also impairs mycelial growth and results in distorted hyphae

IV. Medications

  1. Tolnaftate 1% available OTC in U.S. in creams, solutions, powders, gels and sprays

V. Dosing: Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)

  1. Apply twice daily

VI. Safety

  1. Unknown safety in pregnancy
  2. Unknown safety in Lactation

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Related Studies

Cost: Medications

tolnaftate (on 5/18/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
TOLNAFTATE 1% CREAM Generic OTC $0.10 per gram
TOLNAFTATE 1% POWDER Generic OTC $0.05 per gram

Ontology: Tolnaftate (C0040379)

Definition (NCI) A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi.
Definition (MSH) A synthetic antifungal agent.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D014047
SnomedCT 38166006, 387204001
English Tolnaftate, Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester, Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl Ester, Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl Ester, tolnaftate (medication), Tolnaftate [Chemical/Ingredient], TOLNAFTATE, tolnaftate, Tolnaftate (product), Tolnaftate (substance)
Swedish Tolnaftat
Czech tolnaftát
Finnish Tolnaftaatti
Russian TOLNAFTAT, ТОЛНАФТАТ
Polish Tolnaftat
Japanese トルナフタート, トノフタール, チナクチン, トルナフテート, スポリリン, ハイアラージン
Spanish tolnaftato (producto), tolnaftato (sustancia), tolnaftato, Tolnaftato
French Tolnaftate
German Tolnaftat
Italian Tolnaftato
Portuguese Tolnaftato