II. Indications
- Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
- Other Topical Antifungals are preferred (primarily fungistatic rather than fungicidal)
III. Mechanism
- Naphthalene (2 ring Hydrocarbon extracted from Coal Tar) and Thiocarbamate derivative
- Primarily fungistatic (as opposed to fungicidal), leaving it less effective at resolution than other Antifungals
- Other Topical Antifungals are preferred
- Selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase
- Inhibits ergosterol synthesis, a key component in fungal cell walls
- Also impairs mycelial growth and results in distorted hyphae
IV. Medications
- Tolnaftate 1% available OTC in U.S. in creams, solutions, powders, gels and sprays
V. Dosing: Superficial dermatophyte infections (e.g. Tinea Pedis, Tinea Cruris, Tinea Corporis)
- Apply twice daily
VI. Safety
- Unknown safety in pregnancy
- Unknown safety in Lactation
VII. Resources
- Tolnaftate Cream (DailyMed)
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Related Studies
tolnaftate (on 5/18/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
TOLNAFTATE 1% CREAM | Generic OTC | $0.10 per gram |
TOLNAFTATE 1% POWDER | Generic OTC | $0.05 per gram |
Ontology: Tolnaftate (C0040379)
Definition (NCI) | A thiocarbamate derivative with either fungicidal or fungistatic property. Tolnaftate is a selective, reversible and non-competitive inhibitor of membrane-bound squalene-2,3- epoxidase, an enzyme involved in the biosynthesis of ergosterol. Inhibition leads to the accumulation of squalene and a deficiency in ergosterol, an essential component of fungal cell walls, thereby increasing membrane permeability, disrupting cellular organization and causing cell death. In addition, this agent may also distort the hyphae and stunts mycelial growth in susceptible fungi. |
Definition (MSH) | A synthetic antifungal agent. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D014047 |
SnomedCT | 38166006, 387204001 |
English | Tolnaftate, Carbamothioic acid, methyl(3-methylphenyl)-, O-2-naphthalenyl ester, Carbamothioic Acid, methyl(3-methylphenyl)-, O-2-naphthalenyl Ester, Carbanilic Acid, m,N-dimethylthio-, O-2-naphthyl Ester, tolnaftate (medication), Tolnaftate [Chemical/Ingredient], TOLNAFTATE, tolnaftate, Tolnaftate (product), Tolnaftate (substance) |
Swedish | Tolnaftat |
Czech | tolnaftát |
Finnish | Tolnaftaatti |
Russian | TOLNAFTAT, ТОЛНАФТАТ |
Polish | Tolnaftat |
Japanese | トルナフタート, トノフタール, チナクチン, トルナフテート, スポリリン, ハイアラージン |
Spanish | tolnaftato (producto), tolnaftato (sustancia), tolnaftato, Tolnaftato |
French | Tolnaftate |
German | Tolnaftat |
Italian | Tolnaftato |
Portuguese | Tolnaftato |