II. Indication
III. Mechanism
- Comedolytic
- Synthetic Retinoid analog
IV. Supplied
- Adapalene only
- Gel 0.1% (Over-the-counter in U.S. as of 2017)
- Gel 0.3%
- Cream 0.1%
- Lotion 0.1%
- Combinations
- Adapalene/Benzoyl Peroxide 0.1%/2.5% gel (Epiduo)
- Adapalene/Benzoyl Peroxide 0.3%/2.5% gel (Epiduo Forte)
V. Adverse Effects
- Same as Tretinoin, but less severe
VI. Safety
- Pregnancy Category C
- But generally recommended to avoid in pregnancy (esp. first trimester)
VII. Efficacy
VIII. Reference
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| adapalene (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| ADAPALENE 0.1% CREAM | Generic | $2.85 per gram |
| ADAPALENE 0.1% GEL | Generic OTC | $0.51 per gram |
| ADAPALENE 0.3% GEL | Generic | $0.80 per gram |
| ADAPALENE 0.3% GEL PUMP | Generic | $2.66 per gram |
| ADAPALENE-BNZYL PEROX 0.1-2.5% | Generic | $0.59 per gram |
| ADAPALENE-BNZYL PEROX 0.3-2.5% | Generic | $2.10 per gram |