II. Indication
III. Mechanism
- Comedolytic
- Synthetic Retinoid analog
IV. Supplied
- Adapalene only
- Gel 0.1% (Over-the-counter in U.S. as of 2017)
- Gel 0.3%
- Cream 0.1%
- Lotion 0.1%
- Combinations
- Adapalene/Benzoyl Peroxide 0.1%/2.5% gel (Epiduo)
- Adapalene/Benzoyl Peroxide 0.3%/2.5% gel (Epiduo Forte)
V. Adverse Effects
- Same as Tretinoin, but less severe
VI. Safety
- Pregnancy Category C
- But generally recommended to avoid in pregnancy (esp. first trimester)
VII. Efficacy
VIII. Reference
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Related Studies
adapalene (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
ADAPALENE 0.1% CREAM | Generic | $2.85 per gram |
ADAPALENE 0.1% GEL | Generic OTC | $0.51 per gram |
ADAPALENE 0.3% GEL | Generic | $0.80 per gram |
ADAPALENE 0.3% GEL PUMP | Generic | $2.66 per gram |
ADAPALENE-BNZYL PEROX 0.1-2.5% | Generic | $0.59 per gram |
ADAPALENE-BNZYL PEROX 0.3-2.5% | Generic | $2.10 per gram |
Ontology: adapalene (C0165631)
Definition (NCI) | A topical retinoid-like compound, chemically similar to vitamin A. Although the exact mechanism of action is unknown, adapalene binds to specific retinoic acid receptors in the nucleus, leading to specific gene expression. This agent stimulates skin growth through modulation of cellular differentiation, inflammatory processes and keratinization of follicular epithelial cells. Adapalene may increase dermal sensitivity to ultraviolet radiation. (NCI04) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C063610 |
SnomedCT | 332377001, 391719005, 108903004, 386934008 |
English | 6-(3-(1-adamantyl)-4-methoxyphenyl)-2-naphthoic acid, adapalene, 6-(3-(1-Adamantyl)-4-methoxyphenyl)-2-naphthoic acid, 6-(4-Methoxy-3-tricyclo(3.3.1.13,7)dec-1-ylphenyl)-2-naphthalenecarboxylic Acid, ADAPALENE, retinoids adapalene, adapalene (medication), adapalene [Chemical/Ingredient], Adapalene - chemical, Adapalene - chemical (substance), Adapalene, Adapalene (product), Adapalene (substance) |
Spanish | adapaleno (producto), adapaleno (sustancia), adapaleno |
Ontology: Differin (C0593946)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C063610 |
English | Differin, differin, Allphar brand of adapalene, Differine, Galderma brand of adapalene |
Ontology: adapalene 0.001 MG/MG / Benzoyl Peroxide 0.025 MG/MG Topical Gel [Epiduo] (C2586879)
Concepts | Clinical Drug (T200) |
English | Epiduo 0.1%-2.5% Topical Gel, adapalene 0.001 MG/MG / Benzoyl Peroxide 0.025 MG/MG Topical Gel [Epiduo], Epiduo (adapalene 0.1 % / benzoyl peroxide 2.5 %) Topical Gel, Epiduo, 0.1%-2.5% topical gel, ADAPALENE 0.1 %WW TOPICAL GEL [EPIDUO], ADAPALENE 0.1 %WW / BENZOYL PEROXIDE 2.5 %WW TOPICAL GEL [EPIDUO], Epiduo (adapalene 1 MG / benzoyl peroxide 25 MG) per GM Topical Gel, ADAPALENE 1 mg in 1 g / BENZOYL PEROXIDE 25 mg in 1 g TOPICAL GEL [EPIDUO], ADAPALENE 1 MILLIGRAM In 1 GRAM / BENZOYL PEROXIDE 25 MILLIGRAM In 1 GRAM TOPICAL GEL [EPIDUO], Adapalene/Benzoyl Peroxide 0.1%-2.5% Topical application Gel/Jelly [EPIDUO], Epiduo Pump, 0.1%-2.5% topical gel, ADAPALENE 1 mg in 1 g / BENZOYL PEROXIDE 25 mg in 1 g TOPICAL GEL [Epiduo], Epiduo Pump 0.1%-2.5% Topical Gel |