Medication Causes of Hyperpigmentation

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II. Causes

Heavy Metals
1. Arsenic
2. Bismuth
3. Gold
4. Mercury
5. Silver
Cardiovascular Agents
1. Amiodarone
2. Quinidine
Neuropsychiatric agents
1. Methyldopa
2. Amitriptyline (Elavil)
Chemotherapy
1. Bleomycin
2. Busulfan
3. Cyclophosphamide
4. Daunorubicin
5. Dibromomannitol
6. Doxorubicin
7. Tacrolimus (Prograf)
8. Topical nitrogen mustard
Antimicrobials
1. Chloroquine
2. Clofazimine
3. Hydroxychloroquine (Plaquenil)
4. Ketoconazole
5. Minocycline (and less commonly with other Tetracyclines)
6. Zidovudine
Miscellaneous
1. Oral Contraceptives or Hormone Replacement Therapy
2. Phenothiazines

III. References

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II. Causes

III. References

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