II. Indications

III. Preparations

  1. Cutaneous dermatophytes: Ciclopirox olamine 1% (Loprox)
  2. Onychomycosis: Ciclopirox 8% lacquer (Penlac)

IV. Mechanism: Broad-spectrum activity

  1. Antifungal for dermatophytes and yeast
  2. Some antibacterial activity in vitro
    1. Gram Positive Bacteria
    2. Gram Negative Bacteria

V. Efficacy

  1. Tinea Pedis (Loprox)
    1. More effective than OTC Clotrimazole (Lotrimin)
  2. Onychomycosis (Penlac)
    1. NOT recommended
    2. Requires 48 week application
    3. Minimally better than Placebo for cure rates
    4. Partial clearance rates are also poor

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Cost: Medications

ciclopirox (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
CICLOPIROX 0.77% CREAM Generic $0.34 per gram
CICLOPIROX 0.77% GEL Generic $1.13 per gram
CICLOPIROX 0.77% TOPICAL SUSP Generic $0.85 per ml
CICLOPIROX 1% SHAMPOO Generic $0.56 per ml
CICLOPIROX 8% SOLUTION Generic $3.03 per ml