II. Indications
- Dermatophyte Infection (Tinea Corporis, Tinea Pedis, Tinea Cruris)
- Cutaneous Candidiasis
- Tinea Versicolor
-
Onychomycosis
- Not recommended (low efficacy and a very long course)
III. Mechanism
- Broad-spectrum Antifungal activity
- Antifungal for dermatophytes and yeast
- Some antibacterial activity in vitro
IV. Medications
- Cutaneous dermatophytes
- Ciclopirox Shampoo 1% (Loprox)
- Ciclopirox Lotion, Cream or Gel: 0.77%
-
Onychomycosis (Penlac)
- Ciclopirox 8% lacquer (Penlac)
V. Dosing: Adults and Age >12 years old
- Dermatophyte Infection (Tinea Corporis, Tinea Pedis, Tinea Cruris, Tinea Versicolor) and Cutaneous Candidiasis
- Apply twice daily
-
Onychomycosis (not recommended; low efficacy and a very long course)
- Apply daily to affected nails (over the top of prior application)
- Remove with Alcohol every 7 days
- Requires 48 week application
- Seborrheic Dermatitis
VI. Safety
- Pregnancy Category B
- Unknown safety in Lactation
VII. Efficacy
-
Tinea Pedis (Loprox)
- More effective than OTC Clotrimazole (Lotrimin)
-
Onychomycosis (Penlac)
- NOT recommended
- Requires 48 week application
- Minimally better than Placebo for cure rates
- Partial clearance rates are also poor
VIII. Resources
- Ciclopirox 8% Lacquer Solution (DailyMed)
- Ciclopirox Shampoo (DailyMed)
- Ciclopirox Olamine Cream (DailyMed)
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Related Studies
| ciclopirox (on 10/19/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CICLOPIROX 0.77% CREAM | Generic | $0.21 per gram |
| CICLOPIROX 0.77% GEL | Generic | $0.70 per gram |
| CICLOPIROX 0.77% TOPICAL SUSP | Generic | $0.90 per ml |
| CICLOPIROX 1% SHAMPOO | Generic | $0.36 per ml |
| CICLOPIROX 8% SOLUTION | Generic | $1.70 per ml |