II. Indications
- Antseptics are applied prior to procedures in which the skin is broken
III. Preparations
- Chlorhexidine (Hibiclens)
- Often preferred as Topical Anesthetic prior to procedures
- Avoid Chlorhexidine near eyes (irritation) and inside ear canal (ototoxic)
- Povidone Iodine (Betadine)
- Not affective until it dries
- Isopropyl Alcohol 70%
- Hydrogen Peroxide
IV. Resources
- Antiseptics (DermNetNZ)
- Antiseptics (Stat Pearls)
Images: Related links to external sites (from Bing)
Related Studies
| chlorhexidine (on 7/20/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| CHLORHEXIDINE 0.12% RINSE | Generic | $0.02 per ml |
| CHLORHEXIDINE 4% LIQUID | Generic OTC | $0.02 per ml |
| povidone-iodine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| POVIDONE-IODINE 10% SOLUTION | Generic OTC | $0.02 per ml |
Ontology: Anti-Infective Agents, Local (C0003205)
| Definition (NCI) | A natural or synthetic agent used for local application on skin, mucosa, or cavities, a Topical Anti-Infective Agent, formulated as a sterile solution or cream, commonly displays therapeutic or prophylactic antibiotic properties against infectious viral, bacterial, or protozoal agents by inhibiting growth and survival. (NCI04) |
| Definition (MSH) | Substances used on humans and other animals that destroy harmful microorganisms or inhibit their activity. They are distinguished from DISINFECTANTS, which are used on inanimate objects. |
| Definition (CSP) | substances used topically on humans and other animals that destroy harmful microorganisms or inhibit their growth or activity. |
| Concepts | Pharmacologic Substance (T121) |
| MSH | D000891 |
| SnomedCT | 14319004, 373308008 |
| English | Agents, Local Anti-Infective, Agents, Local Antiinfective, Anti Infective Agents, Local, Antiinfective Agents, Local, Antiseptics, Local Anti Infective Agents, Local Anti-Infective Agents, Local Antiinfective Agents, local antiinfective agent, Agents, Topical Anti-Infective, Agents, Topical Antiinfective, Anti Infective Agents, Topical, Anti-Infective Agents, Topical, Antiinfective Agents, Topical, Topical Anti Infective Agents, Topical Anti-Infective Agents, Topical Antiinfective Agents, LOCAL ANTIINFECT AGENTS, ANTI INFECT AGENTS LOCAL, LOCAL ANTI INFECT AGENTS, ANTIINFECT AGENTS TOPICAL, TOPICAL ANTIINFECT AGENTS, ANTIINFECTIVE AGENTS LOCAL, ANTI INFECT AGENTS TOPICAL, ANTIINFECTIVE AGENTS TOPICAL, ANTIINFECT AGENTS LOCAL, TOPICAL ANTI INFECT AGENTS, antiseptic agents, local anti-infective agents, antiseptic agents (medication), Antiseptic, Antiseptic Agent [TC], Antiseptic Agent, topical anti-infective, local antiseptic, antiseptics, antiseptic, Local anti-infective (product), Local anti-infective, Local antiseptic, Local anti-infective (substance), Anti-Infective Agents, Local, Local anti-infective, NOS, Local antiseptic, NOS, Topical Anti-Infective Agent |
| French | Antiseptiques, Anti-infectieux locaux, Antiinfectieux locaux, Médicaments antiseptiques, Anti-infectieux local, Agents antiseptiques |
| Swedish | Antiinfektiva medel, lokala |
| Czech | antiinfekční látky lokální, antiseptika |
| Finnish | Paikallismikrobilääkkeet |
| Italian | Antinfettivi per uso topico, Antinfettivi per uso locale, Antisettici |
| Russian | PROTIVOINFEKTSIONNYE SREDSTVA LOKAL'NYE, ANTISEPTICHESKIE SREDSTVA, ANTISEPTIKI, PROTIVOINFEKTSIONNYE SREDSTVA MESTNYE, АНТИСЕПТИКИ, АНТИСЕПТИЧЕСКИЕ СРЕДСТВА, ПРОТИВОИНФЕКЦИОННЫЕ СРЕДСТВА ЛОКАЛЬНЫЕ, ПРОТИВОИНФЕКЦИОННЫЕ СРЕДСТВА МЕСТНЫЕ |
| Croatian | ANTIMIKROBNA SREDSTVA, LOKALNA |
| Polish | Leki odkażające miejscowo |
| Japanese | 局所抗感染薬, 局所性抗感染剤, 局所的抗感染薬, 抗感染剤-局所性, 防腐薬(組織), 抗感染薬-局所性 |
| Portuguese | Antissépticos, Anti-Infecciosos Tópicos, Anti-Infecciosos Locais, Agentes Anti-Infecciosos Locais, Fármacos Anti-Infecciosos Locais, Agentes Anti-Infecciosos Tópicos, Agentes Antissépticos |
| Spanish | Antiinfecciosos Locales, antiséptico local (producto), antiséptico local, antinfeccioso local, antinfeccioso local (sustancia), Agentes Antiinfecciosos Locales, Fármacos Antiinfecciosos Locales, antiséptico local (sustancia), Agentes Antiinfecciosos Tópicos, Antisépticos |
| German | Antiseptika, Antiinfektiöse Mittel, lokal anwendbare, Antiinfektiöse Mittel, örtlich anwendbare |
Ontology: Chlorhexidine (C0008196)
| Definition (NCI) | A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. |
| Definition (MSH) | A disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. |
| Definition (CSP) | disinfectant and topical anti-infective agent used also as mouthwash to prevent oral plaque. |
| Definition (PDQ) | A biguanide compound used as an antiseptic agent with topical antibacterial activity. Chlorhexidine is positively charged and reacts with the negatively charged microbial cell surface, thereby destroying the integrity of the cell membrane. Subsequently, chlorhexidine penetrates into the cell and causes leakage of intracellular components leading to cell death. Since gram positive bacteria are more negatively charged, they are more sensitive to this agent. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41544&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=41544&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C364" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D002710 |
| SnomedCT | 17112005, 373568007, 96316004 |
| LNC | LP128648-5 |
| English | Chlorhexidine, 2,4,11,13-Tetraazatetradecanediimidamide, N,N''-bis(4-chlorophenyl)-3,12-diimino-, CHLORHEXIDINE, Chlorhexidine [Chemical/Ingredient], chlorhexidine, Chlorhexidine (product), Chlorhexidine (substance), Chlorhexidine -RETIRED- |
| Swedish | Klorhexidin |
| Czech | chlorhexidin |
| Finnish | Klooriheksidiini |
| Russian | KHLORGEKSIDIN, ХЛОРГЕКСИДИН |
| Croatian | CHLORHEXIDINE |
| Polish | Chlorheksydyna |
| Japanese | クロルヘキシジン, 塩酸クロルヘキシジン |
| Norwegian | Klorheksidin |
| Spanish | clorhexidina-RETIRADO- (concepto no activo), clorhexidina-RETIRADO-, clorhexidina (producto), clorhexidina (sustancia), clorhexidina, Clorhexidina |
| French | Chlorhexidine |
| German | Chlorhexidin |
| Italian | Cloressidina |
| Portuguese | Clorexidina |
Ontology: Disinfectants (C0012682)
| Definition (NCI_NCI-GLOSS) | Any substance or process that is used primarily on non-living objects to kill germs, such as viruses, bacteria, and other microorganisms that can cause infection and disease. Most disinfectants are harsh chemicals but sometimes heat or radiation may be used. |
| Definition (SPN) | A liquid chemical sterilant/high level disinfectant is a germicide that is intended for use as the terminal step in processing critical and semicritical medical devices prior to patient use. Critical devices make contact with normally sterile tissue or body spaces during use. Semicritical devices make contact during use with mucous membranes or nonintact skin. |
| Definition (CSP) | substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity; they are distinguished from antiseptics, which are local antiinfective agents used on humans and other animals. |
| Definition (MSH) | Substances used on inanimate objects that destroy harmful microorganisms or inhibit their activity. Disinfectants are classed as complete, destroying SPORES as well as vegetative forms of microorganisms, or incomplete, destroying only vegetative forms of the organisms. They are distinguished from ANTISEPTICS, which are local anti-infective agents used on humans and other animals. (From Hawley's Condensed Chemical Dictionary, 11th ed) |
| Concepts | Substance (T167) |
| MSH | D004202 |
| SnomedCT | 89216004, 311942001 |
| English | DISINFECTANT, MEDICAL DEVICES, STERILANT, MEDICAL DEVICES, Sterilants, disinfectants (medication), disinfectants, disinfectant, sterilant, Disinfectants, Disinfectant, Disinfectant (substance), Disinfectant, NOS, Disinfectant (substance) [Ambiguous] |
| French | Agents désinfectants, Produits désinfectants, Désinfectants |
| Swedish | Desinfektionsmedel |
| Czech | dezinficiencia, dezinfekční prostředky |
| Finnish | Desinfektioaineet |
| Russian | DEZINFEKTSIONNYE SREDSTVA, DEZINFITSIRUIUSHCHIE SREDSTVA, ДЕЗИНФЕКЦИОННЫЕ СРЕДСТВА, ДЕЗИНФИЦИРУЮЩИЕ СРЕДСТВА |
| Croatian | DEZINFICIJENSI |
| Polish | Środki dezynfekujące |
| Japanese | 殺菌剤, 消毒剤, 殺菌薬, 消毒薬, 殺菌消毒剤 |
| Norwegian | Not Translated[Disinfectants] |
| Spanish | desinfectante (concepto no activo), desinfectante (sustancia), desinfectante, Desinfectantes |
| German | Desinfektionsmittel |
| Italian | Disinfettanti |
| Portuguese | Desinfetantes |
Ontology: Povidone-Iodine (C0032857)
| Definition (NCI) | An iodophor solution containing a water-soluble complex of iodine and polyvinylpyrrolidone (PVP) with broad microbicidal activity. Free iodine, slowly liberated from the polyvinylpyrrolidone iodine (PVPI) complex in solution, kills eukaryotic or prokaryotic cells through iodination of lipids and oxidation of cytoplasmic and membrane compounds. This agent exhibits a broad range of microbicidal activity against bacteria, fungi, protozoa, and viruses. Slow release of iodine from the PVPI complex in solution minimizes iodine toxicity towards mammalian cells. |
| Definition (MSH) | An iodinated polyvinyl polymer used as topical antiseptic in surgery and for skin and mucous membrane infections, also as aerosol. The iodine may be radiolabeled for research purposes. |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D011206 |
| SnomedCT | 386989006, 111144003, 331314000, 326293001 |
| English | Polyvinylpyrrolidone Iodine, Povidone-Iodine, PVP-I, PVP-Iodine, PVP Iodine, Povidone Iodine, 2-Pyrrolidinone, 1-ethenyl-, homopolymer, compd. with iodine, Povidone-iodine [gyn], Povidone-iodine [mouth], Povidone-Iodines, PVP-Iodines, Polyvinylpyrrolidone Iodines, Povidone-iodine [gynaecological use], Povidone-iodine [gynecological use], povidone-iodine (medication), povidone-iodine, Povidone-Iodine [Chemical/Ingredient], POVIDONE-IODINE, iodine pvp, iodine povidone, pvp-iodine, pvp iodine, pvp-i, povidone iodine, Povidone-iodine [mouth] (product), Povidone-iodine [gynecological use] (product), PVP iodine, Povidone iodine, Povidone-iodine, Povidone-iodine product, Povidone iodine (product), Povidone iodine (substance), Povidone-iodine [gynecological use] (substance), Povidone-iodine [mouth] (substance), POVIDONE IODINE |
| French | Polyvinylpyrrolidone iodée, Polyvidone iodée, Povidone iodée, Polyvidone-iode, Polyvinylpyrrolidone-iode, Povidone-iode |
| Swedish | Povidonjod |
| Czech | povidon-jod, betadine, polyvinylpyrrolidon-jod, jodovaný povidon |
| Finnish | Povidonijodi |
| Russian | POLIVINILPIRROLIDON-IOD, POVIDON-IOD, POLIVINILPIRROLIDONA IODID, ПОВИДОН-ИОД, ПОЛИВИНИЛПИРРОЛИДОНА ИОДИД, ПОЛИВИНИЛПИРРОЛИДОН-ИОД |
| Spanish | polividona yodada (sustancia), polividona yodada, PVP Yodado, Povidona Yodada, yodopovidona [uso ginecológico], iodopovidona (bucal), yodopovidona [uso ginecológico] (producto), iodopovidona (bucal) (producto), Yodopovidona, yodopovidona (producto), yodopovidona (sustancia), yodopovidona, Polivinilpirrolidona Yodada |
| Japanese | ポビドンよう素, ポリビニルピロリドンよう素, ポビドン･ヨード, ポリビニルピロリドンヨード, ポビドンヨード, PVPヨード |
| Polish | Jodopowidon |
| Norwegian | Povidon-jod |
| Portuguese | Iodo Povidine, PVP-I, Polivinilpirrolidona-Iodo, Povidona-Iodo, PVP-Iodo |
| German | PVP-Iod, Polyvinylpyrrolidon-Iod, Povidon-Iod-Komplex |
| Italian | Povidone iodio |
Ontology: Antiseptic preparation (C0443072)
| Concepts | Pharmacologic Substance (T121) |
| SnomedCT | 261276004 |
| English | Antiseptic preparation, Antiseptic preparation (product), Antiseptic preparation (substance) |
| Spanish | preparado antiséptico (producto), preparado antiséptico |
Ontology: Betadine (C0699524)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D011206 |
| English | Betadines, Betadine antiseptic, betadine, Betadine |
| French | Bétadine |
| Norwegian | Betadine |
| Czech | Betadine |
Ontology: Hibiclens (C0728728)
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | C010882 |
| English | Hibiclens, hibiclens |
