Medication Causes of Pruritus

Aka: Medication Causes of Pruritus, Drug-Induced Pruritus

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II. Causes

  1. Antimicrobials
    1. Cephalosporins
    2. Itraconazole, Fluconazole, Ketoconazole
    3. Metronidazole (Flagyl)
    4. Quinolone Antibiotics
    5. Penicillins
    6. Tetracyclines
    7. Trimethoprim-Sulfamethoxazole (Septra, Bactrim)
  2. Antihypertensives
    1. ACE Inhibitors
    2. Calcium Channel Blockers
    3. Methyldopa
  3. Hypersensitivity Reaction
    1. Rifampin
    2. Vancomycin
  4. Lipid Lowering Agents
    1. Niacin (common)
    2. Statins
  5. Monoclonal Antibodies and Immunomodulating Agents
    1. Granulocyte-Macrophage Colony Stimulating Factor (Common)
    2. Interleukin-2 (Very Common)
    3. Lapatinib (Tykerb)
    4. Matuzumab (Leukeran)
    5. Paclitaxel
    6. Tamoxifen
  6. Miscellaneous
    1. B Vitamins
    2. Opioids (especially via spinal administration)
    3. Hydroxethyl starch (plasma volume expander, common)
    4. NSAIDS and Aspirin
    5. Quinidine
    6. Topical Ointments with high concentrations of inert oil
    7. Sulfonylurea
    8. Xanthine Oxidase Inhibitors

III. References

  1. Reich (2009) Acta Derm Venereol 89(3): 236-44 [PubMed]
  2. Rupert (2022) Am Fam Physician 105(1): 55-64 [PubMed]

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