II. Indications
- FDA-Approved
- Off-Label
- Behcet's Disease (Meningoencephalitis, Uveitis)
- Membranous Nephropathy
- Ovarian Cancer
III. Mechanism
- See Alkylating Agent
- Antineoplastic aromatic nitrogen mustard
- As with other Alkylating Agents (and nitrogen mustards), cross-links DNA
IV. Medications
- Chlorambucil Tablets (Leukeran): 2 mg
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Alopecia
- Bone Marrow Suppression
- Impaired future fertility
- Secondary Malignancy
- Seizures
VII. Safety
- Avoid in Lactation
- Pregnancy Category D (avoid)
- Use reliable Contraception
- Monitoring
VIII. Drug Interactions
-
Live Vaccines
- Avoid while on Chlorambucil
IX. Resources
- Chlorambucil Tablet (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
Definition (NCI_NCI-GLOSS) | A drug used to treat several types of leukemias and lymphomas. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent. |
Definition (NCI) | An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04) |
Definition (MSH) | A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed) |
Definition (CSP) | nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others; may be a carcinogen. |
Definition (PDQ) | An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43113&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43113&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C362" NCI Thesaurus) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D002699 |
SnomedCT | 387249003, 46009007 |
English | Chlorambucil, Chloraminophene, Chlorbutin, N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid, chlorambucil, 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid, Benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-, 4-[bis(2-chloroethyl)amino]benzenebutanoic acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid, N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid, benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI), butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl), gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid, gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid, p-(N, N-di-2-chloroethyl)aminophenyl butyric acid, p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid, Chlorobutine, Chloraminophen, phenylbutyric acid nitrogen mustard, chloroambucil, Chlorambucilum, para-N,N-di(b-chloroethyl)aminophenylbutyric acid, Chlorbutine, Chlorobutin, N,N-di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid, chlorbutinum, chlorambucil (medication), CHLORAMBUCIL, Chlorambucil [Chemical/Ingredient], cbl, Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-, .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid, Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI), .gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid, p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid, Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-, Phenylbutyric acid nitrogen mustard, N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid, p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid, .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid, 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid, Chloroambucil, Chlorambucil (product), Chlorambucil (substance), CBL, CLB, CHL |
Swedish | Klorambucil |
Czech | chlorambucil |
Finnish | Klorambusiili |
Russian | KHLORAMBUTSIL, ХЛОРАМБУЦИЛ |
Japanese | クロラムブシル |
Italian | Cloraminofene, Clorbutina, Acido N,N-Di-(2-cloroetil)-p-aminofenilbutirrico, Clorambucile |
Croatian | KLORAMBUCIL |
Polish | Chlorambucil, Leukeran |
Portuguese | Clorambucil, Clorambucila |
Spanish | clorambucilo (producto), clorambucilo (sustancia), clorambucilo, Clorambucilo |
French | Chlorambucil |
German | Chlorambucil |