II. Indications

III. Mechanism

  1. See Alkylating Agent
  2. Antineoplastic aromatic nitrogen mustard
    1. As with other Alkylating Agents (and nitrogen mustards), cross-links DNA

IV. Medications

  1. Chlorambucil Tablets (Leukeran): 2 mg

V. Dosing

  1. See other references for disease specific dosing protocols

VI. Adverse Effects

  1. Alopecia
  2. Bone Marrow Suppression
  3. Impaired future fertility
  4. Secondary Malignancy
  5. Seizures

VII. Safety

  1. Avoid in Lactation
  2. Pregnancy Category D (avoid)
    1. Use reliable Contraception
  3. Monitoring
    1. Complete Blood Count

VIII. Drug Interactions

  1. Live Vaccines
    1. Avoid while on Chlorambucil

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Ontology: Chlorambucil (C0008163)

Definition (NCI_NCI-GLOSS) A drug used to treat several types of leukemias and lymphomas. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent.
Definition (NCI) An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. (NCI04)
Definition (MSH) A nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others. Although it is less toxic than most other nitrogen mustards, it has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985). (Merck Index, 11th ed)
Definition (CSP) nitrogen mustard alkylating agent used as antineoplastic for chronic lymphocytic leukemia, Hodgkin's disease, and others; may be a carcinogen.
Definition (PDQ) An orally-active antineoplastic aromatic nitrogen mustard. Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43113&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=43113&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C362" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D002699
SnomedCT 387249003, 46009007
English Chlorambucil, Chloraminophene, Chlorbutin, N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid, chlorambucil, 4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid, Benzenebutanoic acid, 4-(bis(2-chloroethyl)amino)-, 4-[bis(2-chloroethyl)amino]benzenebutanoic acid, 4-[p-[bis(2-chloroethyl)amino]phenyl]butyric acid, N,N-di-2-chloroethyl-gamma-p-aminophenylbutyric acid, benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI), butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl), gamma-(p-bis(2-chloroethyl)aminophenyl)butyric acid, gamma-[p-di(2-chloroethyl)aminophenyl]butyric acid, p-(N, N-di-2-chloroethyl)aminophenyl butyric acid, p-N, N-di-(beta-chloroethyl)aminophenyl butyric acid, Chlorobutine, Chloraminophen, phenylbutyric acid nitrogen mustard, chloroambucil, Chlorambucilum, para-N,N-di(b-chloroethyl)aminophenylbutyric acid, Chlorbutine, Chlorobutin, N,N-di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid, chlorbutinum, chlorambucil (medication), CHLORAMBUCIL, Chlorambucil [Chemical/Ingredient], cbl, Butyric acid, 4-(p-bis(2-chloroethyl)aminophenyl)-, .gamma.-(p-bis(2-chloroethyl)aminophenyl)butyric acid, Benzenebutanoic acid, 4-[bis(2-chloroethyl)amino]- (9CI), .gamma.-[p-Di(2-chloroethyl)aminophenyl]butyric acid, 4-[Bis(2-chloroethyl)amino]benzenebutanoic acid, p-N, N-Di-(.beta.-chloroethyl)aminophenyl butyric acid, Butyric acid, 4-(p-[bis(2-chloroethyl)amino]phenyl)-, Phenylbutyric acid nitrogen mustard, N,N-Di-2-chloroethyl-.gamma.-p-aminophenylbutyric acid, p-(N, N-Di-2-chloroethyl)aminophenyl butyric acid, .gamma.-[p-bis(2-chloroethyl)aminophenyl]butyric acid, 4-[p-[Bis(2-chloroethyl)amino]phenyl]butyric acid, Chloroambucil, Chlorambucil (product), Chlorambucil (substance), CBL, CLB, CHL
Swedish Klorambucil
Czech chlorambucil
Finnish Klorambusiili
Russian KHLORAMBUTSIL, ХЛОРАМБУЦИЛ
Japanese クロラムブシル
Italian Cloraminofene, Clorbutina, Acido N,N-Di-(2-cloroetil)-p-aminofenilbutirrico, Clorambucile
Croatian KLORAMBUCIL
Polish Chlorambucil, Leukeran
Portuguese Clorambucil, Clorambucila
Spanish clorambucilo (producto), clorambucilo (sustancia), clorambucilo, Clorambucilo
French Chlorambucil
German Chlorambucil