II. Indications
III. Mechanism
- See Antibiotic Chemotherapy
- Idarubicin is a anthracycline Aminoglycoside antineoplastic
- Semisynthetic 4-demethoxy analog of Daunorubicin
- Idarubicin inserts between adjacent DNA base pairs
- Blocks DNA Transcription by RNA Polymerase
- Idarubicin also inhibits Topoisomerase 2
- Inhibits normal Nucleotide strand ligation during DNA Replication
- Idarubicin is highly lipophilic
- Allows Idarubicin to more easily cross cell membranes (more than other Anthracyclines)
IV. Medications
- Idarubicin IV Solution: 1 mg/ml in 10 and 20 ml vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Severe skin and soft tissue necrosis on extravasation
- Cardiotoxicity (esp. children)
- Risk of Congestive Heart Failure (esp. with multiple doses)
- Myelosuppression
- Hyperuricemia
- Alopecia
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
- Complete Blood Count
- Liver Function Tests
- Renal Function Tests
- Serum Uric Acid
- Echocardiogram with ejection fraction
VIII. Resources
- Idarubicin Injection Solution (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
| Definition (MSH) | An orally administered anthracycline antineoplastic. The compound has shown activity against BREAST NEOPLASMS; LYMPHOMA; and LEUKEMIA. |
| Definition (NCI_NCI-GLOSS) | An anticancer drug that belongs to the family of drugs called antitumor antibiotics. |
| Definition (NCI) | A semisynthetic 4-demethoxy analogue of the antineoplastic anthracycline antibiotic daunorubicin. Idarubicin intercalates into DNA and interferes with the activity of topoisomerase II, thereby inhibiting DNA replication, RNA transcription and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes more efficiently than other anthracycline antibiotic compounds. |
| Definition (PDQ) | A semisynthetic anthracycline antineoplastic antibiotic derived from daunorubicin. Idarubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Due to its high lipophilicity, idarubicin penetrates cell membranes better than other anthracycline antibiotics. Idarubicin hydrochloride is the therapeutic form of this drug. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39753&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39753&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C562" NCI Thesaurus) |
| Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
| MSH | D015255 |
| SnomedCT | 108786002, 372539000 |
| English | 4 Demethoxydaunorubicin, 4 Desmethoxydaunorubicin, 4-Demethoxydaunorubicin, 4-Desmethoxydaunorubicin, 5,12-Naphthacenedione, 9-acetyl-7-((3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy)-7,8,9,10-tetrahydro-6,9,11-trihydroxy-, (7S-cis)-, (1S,3S)-3-Acetyl-1,2,3,4,6,11-hexahydro-3,5,12-trihydroxy-6,11-dioxo-1-naphthacenyl-3-amino-2,3,6-trideoxy-alpha-L-hexopyranoside, (7S-cis)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-alpha-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione, 4DMDR, 4-Demethoxydaunomycin, DEMETHOXYDAUNORUBICIN 04, Idarubicin [Chemical/Ingredient], IDArubicin, idarubicin, IDARUBICIN, Idarubicin (product), Idarubicin (substance), 4-demethoxydaunorubicin, DMDR, IDA, 4-DMDR, Idarubicin |
| Swedish | Idarubicin |
| Czech | idarubicin |
| Finnish | Idarubisiini |
| Russian | 4-DEMETOKSIDAUNORUBITSIN, IDARUBITSIN, 4-ДЕМЕТОКСИДАУНОРУБИЦИН, ИДАРУБИЦИН |
| Japanese | イダルビシン, 4-デメトキシダウノルビシン |
| German | DEMETHOXYDAUNORUBICIN 04, 4-Demethoxydaunorubicin, Idarubicin |
| Polish | Idarubicyna |
| Spanish | idarrubicina (producto), idarrubicina (sustancia), idarrubicina, 4-Demetoxidaunorrubicina, Idarrubicina |
| French | Idarubicine |
| Italian | Idarubicina |
| Portuguese | 4-Demetoxidaunorubicina, Idarubicina |
