II. Indications
III. Mechanism
- See Antibiotic Chemotherapy
- Idarubicin is a anthracycline Aminoglycoside antineoplastic
- Semisynthetic 4-demethoxy analog of Daunorubicin
- Idarubicin inserts between adjacent DNA base pairs
- Blocks DNA Transcription by RNA Polymerase
- Idarubicin also inhibits Topoisomerase 2
- Inhibits normal Nucleotide strand ligation during DNA Replication
- Idarubicin is highly lipophilic
- Allows Idarubicin to more easily cross cell membranes (more than other Anthracyclines)
IV. Medications
- Idarubicin IV Solution: 1 mg/ml in 10 and 20 ml vials
V. Dosing
- See other references for disease specific dosing protocols
VI. Adverse Effects
- Severe skin and soft tissue necrosis on extravasation
- Cardiotoxicity (esp. children)
- Risk of Congestive Heart Failure (esp. with multiple doses)
- Myelosuppression
- Hyperuricemia
- Alopecia
VII. Safety
- Avoid in Lactation
- Avoid in pregnancy (all trimesters)
- Use reliable Contraception
- Monitoring
- Complete Blood Count
- Liver Function Tests
- Renal Function Tests
- Serum Uric Acid
- Echocardiogram with ejection fraction
VIII. Resources
- Idarubicin Injection Solution (DailyMed)