Definition (NCI)
|
A synthetic alkylating agent. Related to nitrogen mustard, thiotepa alkylates and crosslinks DNA, resulting in the inhibition of DNA replication. (NCI04)
|
Definition (NCI_NCI-GLOSS)
|
An anticancer drug that belongs to the family of drugs called alkylating agents.
|
Definition (MSH)
|
A very toxic alkylating antineoplastic agent also used as an insect sterilant. It causes skin, gastrointestinal, CNS, and bone marrow damage. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), thiotepa may reasonably be anticipated to be a carcinogen (Merck Index, 11th ed).
|
Definition (CSP)
|
alkylating agent used as an antineoplastic in the treatment of carcinoma of the breast, ovary, and bladder, malignant infusions and lymphomas.
|
Definition (PDQ)
|
A synthetic alkylating agent. Related to nitrogen mustard, thiotepa alkylates and crosslinks DNA, resulting in the inhibition of DNA replication. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42933&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=42933&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C875" NCI Thesaurus)
|
Concepts |
Pharmacologic Substance
(T121)
, Hazardous or Poisonous Substance
(T131)
, Organophosphorus Compound
(T115)
|
MSH |
D013852
|
SnomedCT |
387508004, 88997008 |
English |
Thio Tepa, Thio-Tepa, Thiophosphamide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine Sulfide, Aziridine, 1,1',1''-phosphinothioylidynetris-, thiotepa, 1,1',1"-phosphinothioylidynetrisaziridine, N,N',N''-triethylenethiophosphoramide, tris(1-aziridinyl)phosphine sulfide, 1,1',1''-Phosphinothioyldynetrisaziridine, Thiophosphoramide, thiotepa (medication), THIOTEPA, Thiotepa [Chemical/Ingredient], N,N', N''-Triethylenethiophosphoramide, Triethylene thiophosphoramide, 1,1',1''-Phosphinothioylidynetrisaziridine, Tris(1-aziridinyl)phosphine sulfide, TESPA, TSPA, Thiotepa (product), Thiotepa (substance), triethylene thiophosphoramide, triethylenethiophosphoramide, Thiofosfamide, Triethylene Thiophosphoramide, Thiotepa |
Swedish |
Tiotepa
|
Czech |
thiotepa
|
Finnish |
Tiotepa
|
Russian |
TEPA, TRIETILENTIOFOSFORAMID, TIOTEF, TIOFOSFAMID, ТЕПА, ТИОТЭФ, ТИОФОСФАМИД, ТРИЭТИЛЕНТИОФОСФОРАМИД |
Japanese |
トリエチレンチオホスホラミド, チオホスファミド, チオテパ, チオフォスファミド |
Polish |
Tiotepa
|
Spanish |
tiotepa (producto), tiotepa (sustancia), tiotepa, trietilentiofosforamida, Tiofosfamida, Tio-TEPA, Tiotepa, Trietilenotiofosforamida |
French |
Thiophosphamide, Thiotépa |
German |
Thio-Tepa, Thiophosphamid, Thiotepa, Triethylenthiophosphoramid |
Italian |
TioTepa
|
Portuguese |
Tiofosfamida, Tio-TEPA, Tiotepa, Trietilenotiofosforamida |