Medications in G6PD Deficiency

Aka: Medications in G6PD Deficiency, Drug Induced Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficiency, Drug Induced Hemolysis in G6PD

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II. Medications: Avoid in G6PD Deficiency

  1. Anti-parasitic Agents
    1. Primaquine
    2. Pamaquine
    3. Niridazole (Ambilhar)
  2. Sulfonamides
    1. Sulfacetamide
    2. Sulfanilamide
    3. Sulfapyridine
    4. Sulfasalazine
  3. Anti-Bacterials
    1. Furazolidone (Furoxone)
    2. Nitrofurantoin (Macrobid, Furadantin)
    3. Nalidixic Acid
    4. Diaminodiphenyl Sulfone (Dapsone)
    5. Mafenide Cream (Sulfamylon)
  4. Analgesics
    1. Phenacetin
    2. Acetanilid
    3. Phenazopyridine (Pyridium)
  5. Miscellaneous
    1. Quinine
    2. Flutamide (Eulexin)
    3. Methylene Blue
    4. Rasburicase (Elitek)
    5. Isobutyl Nitrite

III. Medications: Use Only With Caution in Mild G6PD Deficiency (NOT with Class I or Nonspherocytic Hemolytic Anemia)

  1. General
    1. Considered safe with caution in mild G6PD (Class 3 G6PD)
    2. Do NOT use in Nonspherocytic Hemolytic Anemia
  2. Analgesics
    1. Acetaminophen
    2. Aspirin
    3. Aurodex
  3. Cardiovascular Agents
    1. Procainamide
    2. Quinidine
  4. Neurologic Agents
    1. Trihexyphenidyl
    2. Levodopa
    3. Phenytoin
  5. Antibiotics
    1. Chloramphenicol
    2. Chloroquine
    3. Isoniazid
    4. Probenecid
    5. Proguanil
    6. Pyrimethamine
    7. Streptomycin
    8. Sulfadiazine
    9. Sulfacytine
    10. Sulfamethoxazole (e.g. Septra, Bactrim)
    11. Sulfisoxazole
    12. Trimethoprim
  6. Antihistamines and Anticholinergics
    1. Antazoline
    2. Benzhexol (Trihexyphenidyl, Artane)
    3. Diphenhydramine (Benadryl)
    4. Tripelennamine (Pyribenzamine)
  7. Miscellaneous
    1. Antipyrine
    2. Ascorbic Acid (Vitamin C)
    3. Vitamin K
    4. Colchicine
    5. Glyburide
    6. Quinine

IV. References

  1. Bubp (2015) PT +40(9):572-4 +PMID: 26417175 [PubMed]

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