II. Indications

  1. Sulfadiazine Systemic
    1. Toxoplasmosis Prevention and Treatment
  2. Silver Sulfadiazine Topical Cream (Silvadene, SSD)
    1. Burn Management

III. Contraindications

  1. Severe Renal Insufficiency
  2. Infants age <2 months old (risk of Kernicterus with systemic Sulfadiazine)

IV. Mechanism

V. Medications

  1. Sulfadiazine Systemic
    1. See Toxoplasmosis
    2. Use limited to Toxoplasmosis Prevention and management (combined with Pyrimethamine and leucovorin)
  2. Silver Sulfadiazine Topical Cream (Silvadene, SSD)
    1. Topical Cream used in Burn Injury
    2. See Burn Management

VI. Dosing

  1. Systemic Sulfadiazine
    1. See Toxoplasmosis
  2. Silver Sulfadiazine Topical (Silvadene Cream)
    1. See Burn Management

VII. Adverse Effects

  1. See Sulfadiazine
  2. Crystalluria
    1. Sulfadiazine is more likely to precipitate in acidic urine
    2. Maintain oral hydration
    3. Reduce dose in Renal Insufficiency

VIII. Drug Interactions

  1. Warfarin
    1. Increases INR
  2. Increases drug levels of other medications
    1. Methotrexate
    2. Phenytoin

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Related Studies

Cost: Medications

silver sulfadiazine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
SILVER SULFADIAZINE 1% CREAM Generic $0.25 per gram

Ontology: Sulfadiazine (C0038675)

Definition (NCI) A synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para amino benzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. (NCI04)
Definition (MSH) One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D013411
SnomedCT 371400009, 74523009, 324410004
LNC LP16339-1, MTHU008484
English Sulfadiazine, Sulphadiazine, Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, Sulphadiazine product, sulfadiazine (medication), urological antibacterial sulfadiazine, sulfadiazine, Sulfadiazine [Chemical/Ingredient], SULFADIAZINE, sulphadiazine, sulfADIAZINE, Sulfadiazine (substance), Sulfadiazine product (product), Sulfadiazine product, Sulfadiazine [dup] (substance), SulfADIAZINE
Swedish Sulfadiazin
Czech sulfadiazin
Finnish Sulfadiatsiini
Russian SUL'FAZIN, SUL'FADIAZIN, СУЛЬФАЗИН, СУЛЬФАДИАЗИН
Japanese テラジア, サルファダイアジン, スルファジアジン
Spanish producto con sulfadiazina (producto), sulfadiazina (producto), producto con sulfadiacina, producto con sulfadiazina, Sulfadiazina, sulfadiacina (sustancia), sulfadiacina, Sulfadiacina, sulfadiazina (sustancia), sulfadiazina
Polish Sulfadiazyna
French Sulfadiazine
German Sulfadiazin
Italian Sulfadiazina
Portuguese Sulfadiazina