II. Indications
- Sulfadiazine Systemic
- Toxoplasmosis Prevention and Treatment
- Silver Sulfadiazine Topical Cream (Silvadene, SSD)
III. Contraindications
- Severe Renal Insufficiency
- Infants age <2 months old (risk of Kernicterus with systemic Sulfadiazine)
IV. Mechanism
- See Sulfonamide
V. Medications
- Sulfadiazine Systemic
- See Toxoplasmosis
- Use limited to Toxoplasmosis Prevention and management (combined with Pyrimethamine and leucovorin)
- Silver Sulfadiazine Topical Cream (Silvadene, SSD)
- Topical Cream used in Burn Injury
- See Burn Management
VI. Dosing
- Systemic Sulfadiazine
- See Toxoplasmosis
- Silver Sulfadiazine Topical (Silvadene Cream)
- See Burn Management
VII. Adverse Effects
- See Sulfadiazine
-
Crystalluria
- Sulfadiazine is more likely to precipitate in acidic urine
- Maintain oral hydration
- Reduce dose in Renal Insufficiency
VIII. Drug Interactions
-
Warfarin
- Increases INR
- Increases drug levels of other medications
IX. Resources
- Sulfadiazine (DailyMed)
- Silver Sulfadiazine (DailyMed)
Images: Related links to external sites (from Bing)
Related Studies
silver sulfadiazine (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
SILVER SULFADIAZINE 1% CREAM | Generic | $0.25 per gram |
Ontology: Sulfadiazine (C0038675)
Definition (NCI) | A synthetic pyrimidinyl sulfonamide derivative, short-acting bacteriostatic Sulfadiazine inhibits bacterial folic acid synthesis by competing with para amino benzoic acid. It is used in combination with pyrimethamine to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. (NCI04) |
Definition (MSH) | One of the short-acting SULFONAMIDES used in combination with PYRIMETHAMINE to treat toxoplasmosis in patients with acquired immunodeficiency syndrome and in newborns with congenital infections. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D013411 |
SnomedCT | 371400009, 74523009, 324410004 |
LNC | LP16339-1, MTHU008484 |
English | Sulfadiazine, Sulphadiazine, Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-, Sulphadiazine product, sulfadiazine (medication), urological antibacterial sulfadiazine, sulfadiazine, Sulfadiazine [Chemical/Ingredient], SULFADIAZINE, sulphadiazine, sulfADIAZINE, Sulfadiazine (substance), Sulfadiazine product (product), Sulfadiazine product, Sulfadiazine [dup] (substance), SulfADIAZINE |
Swedish | Sulfadiazin |
Czech | sulfadiazin |
Finnish | Sulfadiatsiini |
Russian | SUL'FAZIN, SUL'FADIAZIN, СУЛЬФАЗИН, СУЛЬФАДИАЗИН |
Japanese | テラジア, サルファダイアジン, スルファジアジン |
Spanish | producto con sulfadiazina (producto), sulfadiazina (producto), producto con sulfadiacina, producto con sulfadiazina, Sulfadiazina, sulfadiacina (sustancia), sulfadiacina, Sulfadiacina, sulfadiazina (sustancia), sulfadiazina |
Polish | Sulfadiazyna |
French | Sulfadiazine |
German | Sulfadiazin |
Italian | Sulfadiazina |
Portuguese | Sulfadiazina |