Pyrantel

Aka: Pyrantel, Pyrantel Pamoate, Pin-X

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II. Indications

  1. Pinworm
  2. Roundworm
  3. Hookworm (off-label)

III. Mechanism

  1. Depolarizing Neuromuscular Blocking Agent active in Helminths (worms)
    1. Results in persistent Nicotinic Receptor (Acetylcholine) activation
    2. Leads to spastic paralysis of nematodes (e.g. Pinworms, roundworms, Hookworms)

IV. Medications

  1. Pyrantel Pamoate 144 mg/ml suspension (Pin-X): Contains 50 mg/ml of Pyrantel base
  2. Pyrantel Pamoate 720 mg Tablets: Contains 250 mg of Pyrantel base
  3. Pyrantel Pamoate 180 mg Tablets: Contains 62.5 mg of Pyrantel base

V. Dosing: Adults and Children

  1. Pinworms
    1. Pyrantel 11 mg/kg (up to 1000 mg) orally for one dose now and again in 2 weeks
  2. Roundworms
    1. Pyrantel 11 mg/kg (up to 1000 mg) orally for one dose
  3. Hookworms (off-label)
    1. Pyrantel 11 mg/kg (up to 1000 mg) orally daily for 3 days

VI. Pharmacokinetics

  1. Not absorbed

VII. Safety

  1. Not absorbed
  2. Pregnancy Category C
  3. Unknown safety in Lactation

VIII. Resources

  1. Pyrantel Pamoate Suspension (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e862b337-2991-4b56-8584-fd80dccd725f
  2. Pyrantel Pamoate Tablet
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=e68dd24a-93f8-4e2e-a698-d9ad9a7cebac

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