III. Mechanism
-
Depolarizing Neuromuscular Blocking Agent active in Helminths (worms)
- Results in persistent Nicotinic Receptor (Acetylcholine) activation
- Leads to spastic paralysis of nematodes (e.g. Pinworms, roundworms, Hookworms)
IV. Medications
- Pyrantel Pamoate 144 mg/ml suspension (Pin-X): Contains 50 mg/ml of Pyrantel base
- Pyrantel Pamoate 720 mg Tablets: Contains 250 mg of Pyrantel base
- Pyrantel Pamoate 180 mg Tablets: Contains 62.5 mg of Pyrantel base
V. Dosing: Adults and Children
VI. Pharmacokinetics
- Not absorbed
VII. Safety
- Not absorbed
- Pregnancy Category C
- Unknown safety in Lactation
VIII. Resources
- Pyrantel Pamoate Suspension (DailyMed)
- Pyrantel Pamoate Tablet
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Related Studies
Definition (MSH) | A depolarizing neuromuscular-blocking agent, that causes persistent nicotinic activation resulting in spastic paralysis of susceptible nematodes. It is a drug of second-choice after benzimidazoles for treatment of ascariasis, hookworm, and pinworm infections, being effective after a single dose. (From Smith and Reynard, Textbook of Pharmacology, 1992, p920) |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D011715 |
SnomedCT | 36068003, 387193008 |
English | Pyrantel, Pyrimidine, 1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)-, (E)-, PYRANTEL, Pyrantel [Chemical/Ingredient], pyrantel, Pyrantel (product), Pyrantel (substance) |
Swedish | Pyrantel |
Czech | pyrantel |
Finnish | Pyranteeli |
Russian | PIRANTEL, ПИРАНТЕЛ |
Polish | Pirantel |
Spanish | pirantel (producto), pirantel (sustancia), pirantel, Pirantel |
French | Pyrantel |
German | Pyrantel |
Italian | Pirantel |
Portuguese | Pirantel |
Ontology: Pyrantel Pamoate (C0034237)
Definition (MSH) | Broad spectrum antinematodal anthelmintic used also in veterinary medicine. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D011716 |
SnomedCT | 25013003 |
English | Embonate, Pyrantel, Pamoate, Pyrantel, Pyrantel Embonate, Pyrantel Pamoate, pyrantel pamoate (medication), pyrantel base (as pyrantel pamoate), PYRANTEL PAMOATE, pyrantel pamoate, Pyrantel Pamoate [Chemical/Ingredient], pyrantel embonate, pamoate pyrantel, 2-Naphthalenecarboxylic acid, 4,4'-methylenebis(3-hydroxy), compd. with (E)-1,4,5,6-tetrahydro-1-methyl-2-(2-(2-thienyl)ethenyl)pyrimidine (1:1), Pyrantel pamoate, Pyrantel pamoate (substance) |
Swedish | Pyrantelpamoat |
Czech | pyrantelpamoát |
Finnish | Pyranteelipamoaatti |
Russian | PIRANTELA PAMOAT, PIRANTELA EMBONAT, KOMBANTRIN, КОМБАНТРИН, ПИРАНТЕЛА ПАМОАТ, ПИРАНТЕЛА ЭМБОНАТ |
Japanese | ピランテルパモエート, ピランテルエンボネート, エンボン酸ピランテル, パモ酸ピランテル |
Italian | Pirantel embonato, Pirantel pamoato |
Polish | Dekanian pirantelu, Combantrin |
Spanish | pamoato de pirantel (sustancia), pamoato de pirantel, Embonato de Pirantel, Pamoato de Pirantel |
French | Pyrantel pamoate |
German | Pyrantelembonat, Pyrantelpamoat |
Portuguese | Embonato de Pirantel, Pamoato de Pirantel |