Fourth Generation Fluoroquinolone

Aka: Fourth Generation Fluoroquinolone, Fourth Generation Quinolone, Trovafloxacin, Trovan

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II. Preparations

  1. See Delafloxacin (Baxdela)
  2. Trovafloxacin (Trovan)

III. Pharmacology: Activity Spectrum

  1. Gram Negative Bacteria (Enterobacteriaceae)
  2. Atypical Bacteria
  3. Staphylococcus aureus (Methicillin susceptible)
  4. Streptococci
    1. Improved coverage over Third Generation Quinolones
  5. Anaerobic Bacteria
    1. Not covered by Third Generation Quinolones
  6. Pseudomonas aeruginosa coverage varies
    1. Delafloxacin (Baxdela) has good Pseudomonas coverage
    2. Trovafloxacin (Trovan) has minimal Pseudomonas coverage

IV. Indications

  1. Intra-abdominal infections
  2. Avoid Trovafloxacin in UTI (low urine concentrations)

V. References

  1. King (2000) Am Fam Physician 61(9):2741-8 [PubMed]
  2. O'Donnell (2000) Infect Dis Clin North Am 14(2):489-513 [PubMed]
  3. Oliphant (2002) Am Fam Physician 65(3):455-64 [PubMed]
  4. Owens (2000) Med Clin North Am 84(6):1447-69 [PubMed]

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