II. Indications
-
Staphylococcus Infection
- Staphylococcus aureus
- Staphylococcus epidermidis
- Specific Infections
- Skin Infection
- Soft tissue infection
- Lymphatic infection
- Bone Infection
- Joint infection
III. Mechanism
- Same action to Natural Penicillins
- Prevents Penicillinase hydrolysis of Beta lactam ring
IV. Mechanism: Bacterial Resistance mechanisms
- Alteration of Bacterial cell wall
V. Mechanism: Activity Spectrum
- Same as for Natural Penicillins
VI. Preparations: Oral
- Directions
- Take on an empty Stomach
- Take more than 1 hour before or two hours after food
- Cloxacillin (Cloxapen) 250-500 mg PO qid
- Dicloxacillin (Dynapen)
- Adult: 125 to 500 mg PO qid
- Child: 12.5 to 25 mg/kg/day PO divided qid
VII. Preparations: Parenteral
- Methicillin (Staphcillin)
- Nafcillin (Nafcil, Unipen)
- Adult: 1 to 2 grams IM or IV every 4 hours
- Child: 50 to 200 mg/kg/day divided every 4 to 6 hours
- Oxacillin (Bactocill)
- Adult: 1 to 2 grams IM or IV every 4 to 6 hours
VIII. Adverse effects
- Nephritis (Methicillin)
- Venous inflammation (Nafcillin)
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Related Studies
| dicloxacillin (on 11/23/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
| DICLOXACILLIN 250 MG CAPSULE | Generic | $0.43 each |
| DICLOXACILLIN 500 MG CAPSULE | Generic | $1.01 each |