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Ontology:
Carbenicillin
(C0006976)
|
Definition (NCI)
|
A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal and beta-lactamase resistant activity. Carbenicillin acylates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.
|
|
Definition (MSH)
|
Broad-spectrum semisynthetic penicillin derivative used parenterally. It is susceptible to gastric juice and penicillinase and may damage platelet function.
|
| Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
| MSH |
D002228
|
| SnomedCT |
34731007, 372713001 |
| LNC |
LP16062-9, MTHU007966 |
| English |
Carbenicillin, Carboxybenzyl Penicillin, Penicillin, Carboxybenzyl, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((carboxyphenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta))-, carbenicillin, Carbenicillin [Chemical/Ingredient], Carbenicillin (product), Carbenicillin (substance), CARBENICILLIN |
| Swedish |
Karbenicillin
|
| Czech |
karbenicilin
|
| Finnish |
Karbenisilliini
|
| Russian |
KARBOKSIBENZILPENITSILLIN, KARBENITSILLIN, КАРБЕНИЦИЛЛИН, КАРБОКСИБЕНЗИЛПЕНИЦИЛЛИН |
| Japanese |
カルベニシリン, カルボキシベンジルペニシリン, カルベニシリンナトリウム |
| Croatian |
CARBENICILLIN
|
| Polish |
Karbenicylina
|
| Spanish |
Carboxibencilpenicilina, carbenicilina (producto), carbenicilina (sustancia), carbenicilina, Carbenicilina, Carboxibencil Penicilina |
| French |
Carbénicilline
|
| German |
Carbenicillin, Carboxybenzylpenizillin |
| Italian |
Carbenicillina
|
| Portuguese |
Carbenicilina, Carboxibenzilpenicilina |
Ontology:
Piperacillin
(C0031955)
|
Definition (NCI)
|
A broad-spectrum semisynthetic, ampicillin-derived ureidopenicillin antibiotic. Piperacillin binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, a critical component of the bacterial cell wall. This blockade leads to the interruption of cell wall synthesis, consequently, leading to bacterial cell growth inhibition and cell lysis.
|
|
Definition (MSH)
|
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
|
| Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
| MSH |
D010878
|
| SnomedCT |
372836004, 74575000 |
| LNC |
LP16256-7, MTHU008471 |
| English |
Pipercillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-, piperacillin, piperacillin (medication), Piperacillin [Chemical/Ingredient], pipercillin, (2S,5R,6R)-6-((R)-2-(4-Ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid Monohydrate, PIPERACILLIN, Piperacillin (product), Piperacillin (substance), Piperacillin |
| Swedish |
Piperacillin
|
| Czech |
piperacilin
|
| Finnish |
Piperasilliini
|
| Russian |
PIPERATSILLIN, ПИПЕРАЦИЛЛИН |
| Japanese |
ピシリアント, プランジン, ホモスリン, ペンマリン, ペントシリン, ピペラシリンナトリウム, ピペユンシン, アルカベミン, ピペラシリン |
| Italian |
Pipercillina, Piperacillina |
| Croatian |
PIPERACILIN
|
| Polish |
Piperacylina
|
| Spanish |
piperacilina (producto), piperacilina (sustancia), piperacilina, Piperacilina |
| French |
Pipéracilline
|
| German |
Piperacillin
|
| Portuguese |
Piperacilina
|
Ontology:
Ticarcillin
(C0040193)
|
Definition (NCI)
|
A broad-spectrum, semi-synthetic penicillin antibiotic with bactericidal activity. Similar to carbenicillin in action, ticarcillin inactivates the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation prevents the cross-linkage of peptidoglycan strands, thereby inhibiting the third and last stage of bacterial cell wall synthesis. This leads to incomplete bacterial cell wall synthesis and eventually causes cell lysis.
|
|
Definition (MSH)
|
An antibiotic derived from penicillin similar to CARBENICILLIN in action.
|
| Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
| MSH |
D013982
|
| SnomedCT |
1148001, 372577006 |
| LNC |
LP16291-4, MTHU008492 |
| English |
Ticarcillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((carboxy-3-thienylacetyl)amino)-3,3-dimethyl-7-oxo-, (2S-(2alpha,5alpha,6beta(S*)))-, ticarcillin, Ticarcillin [Chemical/Ingredient], ticarcillin (medication), TICARCILLIN, Ticarcillin (product), Ticarcillin (substance), Ticarcillin, NOS |
| Swedish |
Ticarcillin
|
| Czech |
tikarcilin
|
| Finnish |
Tikarsilliini
|
| Russian |
TIKARTSILLIN, BRL 2288, ТИКАРЦИЛЛИН |
| Japanese |
チカルシリン, チカルシリンナトリウム |
| Polish |
Tikarcylina
|
| Spanish |
ticarcilina (producto), ticarcilina (sustancia), ticarcilina, Ticarcilina |
| French |
Ticarcilline
|
| German |
Ticarcillin
|
| Italian |
Ticarcillina
|
| Portuguese |
Ticarcilina
|
Ontology:
Timentin
(C0076686)
| Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
|
| MSH |
C043215
|
| English |
Timentin, Timentin ADD-Vantage, timentin |
