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Definition (NCI)
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A semi-synthetic, broad-spectrum naphthacene antibiotic produced by the bacterium Streptomyces aureofaciens. Demeclocycline binds to bacterial 30S ribosomal subunit and prevents binding of aminoacyl-tRNA to the mRNA-ribosome complex, thereby inhibiting protein synthesis. Demeclocycline also inhibits the effect of vasopressin on the renal tubules, thereby causing diuresis.
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Definition (MSH)
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A TETRACYCLINE analog having a 7-chloro and a 6-methyl. Because it is excreted more slowly than TETRACYCLINE, it maintains effective blood levels for longer periods of time.
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| Concepts |
Antibiotic
(T195)
, Organic Chemical
(T109)
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| MSH |
D003707
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| SnomedCT |
372779007, 5737008, 10324005 |
| LNC |
LP14988-7, MTHU002291 |
| English |
Demeclocycline, Demethylchlortetracycline, 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-, demeclocycline, 7-Chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-1,11-dioxo-2-naphthacenecarboxamide, Demeclocycline [Chemical/Ingredient], DEMECLOCYCLINE, Demeclocycline (product), Demeclocycline (substance) |
| Swedish |
Demeklocyklin
|
| Czech |
demethylchlortetracyklin
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| Finnish |
Demeklosykliini
|
| Russian |
DEMETILKHLORTETRATSIKLIN, DEMEKLOTSIKLIN, ДЕМЕКЛОЦИКЛИН, ДЕМЕТИЛХЛОРТЕТРАЦИКЛИН |
| Japanese |
デメクロサイクリン, デメチルクロルテトラサイクリン |
| Italian |
Demetilclortetraciclina, Demeclociclina |
| Polish |
Demeklocyklina
|
| Spanish |
demeclociclina (producto), demeclociclina (sustancia), demeclociclina, demetilclortetraciclina, Demeclociclina, Demetilclortetraciclina |
| French |
Déméclocycline, Déméthylchlortétracycline |
| German |
Demeclocyclin, Demethylchlortetracyclin |
| Portuguese |
Demeclociclina, Demetilclortetraciclina |
