II. Indications

III. Mechanism

  1. Ceftaroline Fosamil is infused and hydrolyzed to the active form, Ceftaroline
  2. Inactivates Penicillin-binding Proteins on the inner membrane of the Bacterial cell wall (similar to other beta lactams)
    1. Interferes with cross-linkage of peptidoglycan chains, reducing Bacterial cell wall strength and rigidity

IV. Dosing: Adult

  1. Standard Dosing
    1. Give 600 mg IV every 12 hours infused over 5 to 60 minutes
  2. Renal Dosing
    1. eGFR 31 to 50 ml/min: 400 mg IV every 12 hours
    2. eGFR 15 to 30 ml/min: 300 mg IV every 12 hours
    3. eGFR <15 or Hemodialysis: 200 mg IV every 12 hours

V. Dosing: Child

  1. Age 2 months to 2 years
    1. Give 8 mg/kg IV every 12 hours
  2. Age >2 years and weight <33 kg
    1. Give 12 mg/kg IV every 8 hours
  3. Age >2 years and weight >33 kg (Adult dosing)
    1. Give 400 mg IV every 8 hours OR
    2. Give 600 mg IV every 12 hours

VI. Pharmacokinetics

  1. Ceftaroline Fosamil is hydrolyzed to the active form, Ceftaroline in vivo
  2. Elimination Half-Life: 3 hours

VII. Adverse Effects

VIII. Safety

  1. Pregnancy Category B
  2. Considered safe in Lactation

X. References

  1. Steed (2010) Pharmacotherapy 30(4):375-89 +PMID: 20334458

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Related Studies

Ontology: ceftaroline (C2001521)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C490727
SnomedCT 702414006
LNC LP172558-1, MTHU046359
English ceftaroline, CEFTAROINE, Ceftaroline (substance), Ceftaroline, CEFTAROLINE

Ontology: ceftaroline fosamil (C2001525)

Definition (NCI) An N-phosphono prodrug of the fifth-generation cephalosporin derivative ceftaroline with antibacterial activity. Ceftaroline fosamil is hydrolyzed to the active form ceftaroline in vivo. Ceftaroline binds to and inactivates penicillin-binding proteins (PBPs) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C515501
SnomedCT 702415007
English Ceftaroline Fosamil, (6R,7R)-7-(((2Z)-(Ethoxyimino)(5-(phosphonoamino)-1,2,4-thiadiazol-3-yl)acetyl)amino)-3-((4-(1-methylpyridinium-4-yl)thiazol-2-yl)sulfanyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-2-carboxylate Monoacetate Monohydrate, ceftaroline fosamil, CEFTAROLINE FOSAMIL, Ceftaroline fosamil, Ceftaroline fosamil (substance)
Japanese セフタロリンホサミル