III. Contraindications

IV. Mechanism

  1. See Penicillin
  2. See Natural Penicillin for activity spectrum
  3. Penicillin VK (Potassium salt of Penicillin V) is the typical Penicillin V formulation in U.S.

V. Medications

  1. Penicillin VK Tablets: 250 and 500 mg
  2. Penicillin VK Oral solution 125 mg/5 ml and 250 mg/5ml
    1. May keep up to 14 days in refrigerator
    2. Solutios horrible taste is typically not tolerated by children

VI. Dosing

  1. See Anthrax
  2. Typical Dose
    1. Adult (age>12 years): 250 to 500 mg orally 4 times daily
    2. Child (age <12 years): 25 to 50 mg/kg/day divided 3 to 4 times daily
  3. Group A Streptococcal Pharyngitis
    1. Adult: 500 mg orally 2 to 3 times daily for 10 days
    2. Child weight <27 kg: 250 mg orally 2 to 3 times daily for 10 days
    3. Child weight >27 kg: 500 mg orally 2 to 3 times daily for 10 days
  4. Rheumatic Fever Prophylaxis
    1. Adult or Child: 250 mg orally twice daily
  5. Acute Necrotizing Ulcerative Gingivitis (ANUG or Vincent's Stomatitis)
    1. Adult: 250 mg orally every 4 to 6 hours
  6. Asplenia Infection Prophylaxis
    1. Indicated in children with Sickle Cell Anemia up to age 5 years
    2. Child age <3 years: 125 mg orally twice daily
    3. Child age 3 to 5 years: 250 mg orally twice daily

VII. Adverse Effects

VIII. Safety

  1. Considered safe in pregnancy (Pregnancy Category B)
  2. Considered safe in Lactation

X. References

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Related Studies

Cost: Medications

penicillin v (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PENICILLIN VK 125 MG/5 ML SOLN Generic $0.07 per ml
PENICILLIN VK 250 MG TABLET Generic $0.06 each
PENICILLIN VK 250 MG/5 ML SOLN Generic $0.05 per ml
PENICILLIN VK 500 MG TABLET Generic $0.10 each

Ontology: Penicillin V (C0030840)

Definition (NCI) A member of the penicillin family exhibiting broad-spectrum antibiotic property. Penicillin V binds to penicillin binding proteins (PBP), the enzymes that catalyze the synthesis of peptidoglycan, which is a critical component of the bacterial cell wall. This leads to the interruption of cell wall synthesis, consequently leading to bacterial cell growth inhibition and cell lysis.
Definition (MSH) A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D010404
SnomedCT 39359008, 372725003, 386538002
LNC LP16238-5, MTHU008468
English Fenoxymethylpenicillin, Penicillin, Phenoxymethyl, Phenoxymethylpenicillin, Phenoxymethyl Penicillin, 4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3,3-dimethyl-7-oxo-6-((phenoxyacetyl)amino)-, (2S-(2alpha,5alpha,6beta))-, Penicillin V, Penicillin V [Chemical/Ingredient], phenoxymethyl penicillin, penicillin v, penicillins v, fenoxymethylpenicillin, penicillin V (discontinued), penicillin V (medication), phenoxymethylpenicillin, Phenoxymethylpenicillin (product), penicillin V, PENICILLIN V, Penicillin V (product), Penicillin V (substance), penV, Phenoxymethyl penicillin, Penicillin V, NOS
Swedish Penicillin V
Czech V-penicilin, fenoxymethylpenicilin
Spanish fenoximetilpenicilina, penicilina V, fenoximetilpenicilina (sustancia), fenoximetilpenicilina (producto), penicilina V (producto), penicilina V (sustancia), Penicilina Fenoximetil, Penicilina V
Finnish Fenoksimetyylipenisilliini
Russian PENITSILLIN V, PENITSILLIN, FENOKSIMETIL, FENOKSIMETILPENITSILLIN, ПЕНИЦИЛЛИН V, ПЕНИЦИЛЛИН, ФЕНОКСИМЕТИЛ, ФЕНОКСИМЕТИЛПЕНИЦИЛЛИН
Japanese フェノキシメチルペニシリン, ペニシリンV, ペニシリン-フェノキシメチル
French Pénicilline V, Phénoxyméthylpénicilline
Polish Penicylina fenoksymetylowa, Penicylina V
German Penicillin V, Penicillin, Phenoxymethyl-, Phenoxymethylpenicillin
Italian Penicillina V
Portuguese Fenoximetilpenicilina, Penicilina V

Ontology: Penicillin V Potassium (C0700553)

Definition (NCI) The potassium salt of penicillin V, a member of the penicillin antibiotic family with broad-spectrum bactericidal activity. Penicillin V binds to and inactivates penicillin-binding proteins (PBPs), enzymes located on the inner membrane of the bacterial cell wall, resulting in the weakening of the bacterial cell wall and cell lysis. PBPs participate in the terminal stages of assembling the bacterial cell wall, and in reshaping the cell wall during cell division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D010404
SnomedCT 56723006
LNC LP16335-9, MTHU019827
English Potassium, Penicillin V, penicillin V potassium (medication), PENICILLIN V POTASSIUM, Penicillin V Potassium [Chemical/Ingredient], penicillins potassium v, penicillin potassium v, penicillin v potassium, Penicillin V Potassium (obsolete), penicillin V potassium, Penicillin V potassium, Phenoxymethyl penicillin potassium, Penicillin V potassium (substance), Penicillin V Potassium
German Penicillin-V-Kalium
French Pénicilline V potassique, Pénicilline V de potassium, Phénoxyméthylpénicilline de potassium, Phénoxyméthylpénicilline potassique
Spanish fenoximetil penicilina potásica, penicilina V potásica (sustancia), penicilina V potásica