Ivermectin

Aka: Ivermectin, Mectizan, Stromectol

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II. Indications

  1. Scabies (refractory to Permethrin 5%)
  2. Head Lice
  3. Strongyloidiasis
  4. Onchocerciasis

III. Contraindications

  1. Pregnancy first trimester
  2. Weight <15 kg

IV. Mechanism

  1. Developed initially as veterinary anti-parasitic agent
  2. Related to macrolide Antibiotics
  3. Decreases Nerve Impulse transmission
    1. Potentiates GABA-gated chloride channels
    2. Results in Helminth paralysis

V. Medications

  1. Ivermectin 3 mg tablet
  2. Dose 200 mcg/kg equivalents
    1. Weight 15 to 24 kg: 3 mg
    2. Weight 25 to 35 kg: 6 mg
    3. Weight 36 to 50 kg: 9 mg
    4. Weight 51 to 65 kg: 12 mg
    5. Weight 66 to 79 kg: 15 mg

VI. Dosing: FDA Approved for Adult and Child (weight >=15 kg)

  1. General
    1. Take on an empty Stomach with water
  2. Strongyloidiasis
    1. Ivermectin 200 mcg/kg orally for 1 dose
    2. Consider repeat up to monthly doses in Immunocompromised patients (e.g. HIV Infection)
  3. Onchocerciasis
    1. Ivermectin 150 mcg/kg orally for 1 dose, repeated every 3 to 12 months

VII. Dosing: Off-Label for Adult and Child (weight >=15 kg)

  1. Scabies or Head Lice (not FDA approved)
    1. Ivermectin 200 mcg/kg orally for 1 dose, and repeat dose in 10 days
  2. Crusted Scabies
    1. Ivermectin 200 mcg/kg orally on days 1, 2, 8, 9, 15 (and consider on days 22 and 29 in more severe cases)
    2. Use in combination with full body Permethrin 5% daily for 7 days, then twice daily until resolution
  3. Public Lice
    1. Ivermectin 250 mcg/kg orally, then repeated in 2 weeks
  4. Cutaneous Larva Migrans
    1. Ivermectin 200 mcg/kg orally daily for 1 to 2 days
  5. Roundworm Infections
    1. Ivermectin 150 to 200 mcg/kg orally for 1 dose

VIII. Pharmacokinetics

  1. Peak Level: 3-6 hours after intake
  2. Half-Life: >12 hours
  3. Metabolized by Cyp 3A4
  4. Crosses blood brain barrier via P-Glycoprotein (ABCB1 Transporter)

IX. Adverse Effects: Mazzotti Reaction (Immunologic Reaction in Onchocerciasis to Parasite Death)

  1. Nausea
  2. Fever
  3. Headache
  4. Arthralgias
  5. Urticaria
  6. Ophthalmic complications

X. Adverse Effects: Toxicity or Overdose

  1. Background
    1. Lower Doses <500 mg in adults and <5mg/kg in children are typically without reaction
    2. High doses, however, may result in life threatening adverse effects (Seizures, coma, death)
      1. In 2021, patients were taking very high doses (>600 mg daily) for COVID-19 (based on little evidence of benefit)
      2. Patients also ingested high risk formulations (topical Ivermectin, veterinary Ivermectin)
    3. Findings typically resolve within 6-8 hours of ingestion
  2. Gastrointestinal Findings
    1. Nausea or Vomiting
    2. Abdominal Pain
    3. Diarrhea
  3. Neurologic Findings
    1. Headache
    2. Dizziness
    3. Hallucinations
    4. Confusion
  4. Cardiopulmonary Findings
    1. Hypotension
    2. Tachycardia
  5. Skin Findings
    1. Urticaria
    2. Edema
  6. Management
    1. See Unknown Ingestion
    2. Activated Charcoal
      1. Indicated in early presentation of large ingestion
    3. Supportive Management
      1. ABC Management
      2. Benzodiazepines for Seizures
      3. Consider Intravenous Lipid Emulsion

XI. Safety

  1. Safe in children >15 kg (33 pounds)
  2. Considered safe in Lactation (after first week of life)
    1. Poorly excreted into Breastmilk
  3. Pregnancy Category X in first trimester
    1. Unknown or Pregnancy Category C in later pregnancy

XII. Efficacy: Scabies

  1. Studies show efficacy over Lindane for Scabies
    1. Madan (2001) J Dermatol 28:481-4 [PubMed]
  2. Permethrin 5% appears to be more effective for Scabies
    1. Usha (2000) J Am Acad Dermatol 42:236-40 [PubMed]

XIII. Drug Interactions

  1. Warfarin
    1. Ivermectin may increase INR levels

XIV. Resources

  1. Ivermectin Tablet (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=847a1dd7-d65b-4a0e-a67d-d90392059dac

XV. References

  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  2. Tomaszewski (2021) Crit Dec Emerg Med 35(9): 32
  3. Meinking (1995) N Engl J Med 333:26 [PubMed]
  4. Fawcett (2003) Am Fam Physician 68(6):1089-92 [PubMed]

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Related Studies

Cost: Medications

ivermectin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
IVERMECTIN 1% CREAM Generic $5.01 per gram
IVERMECTIN 3 MG TABLET Generic $3.68 each
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

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