III. Mechanism: Lipophilic Drug Overdose

  1. Sequesters lipophilic drugs (forms micelle)
    1. Draws out lipophilic agents from aqueous and intracellular spaces
  2. Increases Cardiac Function (possible)
    1. Increases intracellular Fatty Acids triggering increased ATP in cardiac tissue
    2. Increases intracellular Calcium

IV. Dosing: Lipophilic Drug Overdose

  1. Intralipid 20% emulsion
    1. Bolus: 1.5 ml/kg (Lean Body Mass) IV over 2-3 minutes (may be repeated once)
    2. Maintenance (start immediately): 0.25 ml/kg/min IV
      1. Typically 15 ml/kg (Lean Body Mass) IV over 60 minutes

V. Adverse Effects

VII. References

  1. Yen (2015) Crit Dec Emerg Med 29(10):18-23

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