II. Indications
III. Mechanism
- Nonselective Beta Blocker (Beta-1 and Beta-2 Adrenergic Blockade)
IV. Dosing
- Start 10 mg orally twice daily
- Target 20-40 mg/day divided twice daily
- Maximum 60 mg/day
V. Pharmacokintics
- Mildly lipophilic
- Moderate first pass liver metabolism
- Hepatic elimination
- CYP2D6 metabolism
VI. Adverse Effects
- See Beta Blocker
VII. Safety
- Pregnancy Category C
- Safe in Lactation
VIII. Resources
IX. References
- (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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