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Definition (NCI)
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A propanolamine derivative and a non-selective beta-adrenergic antagonist with antihypertensive property. Timolol competitively binds to beta-1-adrenergic receptors in the heart and vascular smooth muscle and beta-2-receptors in the bronchial and vascular smooth muscle, resulting in a decrease in beta-adrenergic stimulation. Beta-1-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta-2-blockade results in an increase in peripheral vascular resistance. The ultimate results include vasodilation, and negative chronotropic and inotropic cardiac effects. In addition, timolol reduces intra-ocular pressure possibly by decreasing aqueous humor production by reduction of blood flow to the ciliary processes and cAMP synthesis.
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Definition (MSH)
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A beta-adrenergic antagonist similar in action to PROPRANOLOL. The levo-isomer is the more active. Timolol has been proposed as an antihypertensive, antiarrhythmic, antiangina, and antiglaucoma agent. It is also used in the treatment of MIGRAINE DISORDERS and tremor.
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| Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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| MSH |
D013999
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| SnomedCT |
372880004, 85591001 |
| LNC |
LP16293-0, MTHU018379, LA14716-7 |
| English |
Timolol, (S)-1-((1,1-Dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadazol-3-yl)oxy)-2-propanol, 2-Propanol, 1-((1,1-dimethylethyl)amino)-3-((4-(4-morpholinyl)-1,2,5-thiadiazol-3-yl)oxy)-, (S)-, (S)-1-(tert-Butylamino)-3-((4-morpholino-1,2,5-thiadiazol-3-yl)oxy)propan-2-ol, timolol (ophthalmic) (medication), timolol (medication), timolol (ophthalmic), Timolol, Ophthalmic, timolol ophthalmic, timolol, Timolol [Chemical/Ingredient], TIMOLOL, Timolol (product), Timolol (substance) |
| Swedish |
Timolol
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| Czech |
timolol
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| Finnish |
Timololi
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| Russian |
TIMOLOL, ТИМОЛОЛ |
| Japanese |
チモレート, チマバック, ファルチモ, ブルンネ, チモプトール, マレイン酸チモロール, リズモン, チアブート, チモロールT, チモロール |
| Polish |
Timolol
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| Spanish |
timolol (producto), timolol (sustancia), timolol, Timolol |
| French |
Timolol
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| German |
Timolol
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| Italian |
Timololo
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| Portuguese |
Timolol
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