III. Contraindications

  1. Contraindicated in moderate to severe liver disease (and Exercise caution in renal disease)

IV. Dosing

  1. Take 10 mg once daily

V. Adverse Effects

  1. See Selective Alpha-1a Antagonist
  2. Postural Hypotension (esp. when combined with Antihypertensives)
  3. Floppy Iris Syndrome
  4. Ejaculatory Dysfunction (class effect)
    1. Alfuzosin ER is least likely to cause ejaculatory dysfunction of the selective alpha agents

VI. Drug Interactions

VIII. References

  1. Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
  2. Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022
    1. https://www.ncbi.nlm.nih.gov/books/NBK556066/

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

alfuzosin (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
ALFUZOSIN HCL ER 10 MG TABLET Generic $0.12 each

Ontology: alfuzosin (C0051150)

Definition (NCI) A synthetic quinazoline compound with smooth muscle relaxing activity. Alfuzosin selectively binds to and antagonizes alpha-1-adrenergic receptors in smooth muscle of the bladder neck and prostate, thereby relaxing the smooth muscle and decreasing the obstruction and urethral resistance seen with benign prostate hyperplasia (BPH) and prostate cancer. This agent also blocks alpha-1-adrenergic receptors in peripheral vascular smooth muscle, which leads to vasodilatation and a subsequent decrease in peripheral vascular resistance.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C047638
SnomedCT 349912006, 395954002
English alfuzosin, N-(3-((4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide, alphuzosine, alfusozine, N-(3-((4-Amino-6,7-dimethoxy-2-quinazolinyl)methylamino)propyl)tetrahydro-2-furancarboxamide, (+/-)-N-(3-((4-amino-6,7-dimethoxyquinazolin-2-yl)(methyl)amino)propyl)tetrahydrofuran-2-carboxamide, alfuzosin [Chemical/Ingredient], ALFUZOSIN, Alfuzosin, Alfuzosin (product), Alfuzosin (substance)
Spanish alfuzosina (producto), alfuzosina (sustancia), alfuzosina

Ontology: UroXatral (C1174734)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C047638
English UroXatral, xatral, Uroxatral, Xatral, Altana Pharma brand of alfuzosin hydrochloride, Benestan, Sanofi Synthelabo brand of alfuzosin hydrochloride, Sanofi Winthrop brand of alfuzosin hydrochloride, Sanofi brand of alfuzosin hydrochloride, Urion, Zambon brand of alfuzosin hydrochloride