II. Indications
III. Contraindications
- Contraindicated in moderate to severe liver disease (and Exercise caution in renal disease)
IV. Dosing
- Take 10 mg once daily
V. Adverse Effects
- See Selective Alpha-1a Antagonist
- Postural Hypotension (esp. when combined with Antihypertensives)
- Floppy Iris Syndrome
- Ejaculatory Dysfunction (class effect)
- Alfuzosin ER is least likely to cause ejaculatory dysfunction of the selective alpha agents
VI. Drug Interactions
- Avoid all Selective Alpha-1a Antagonists with strong CYP3A4 inhibitors (e.g. Ketoconazole, Clarithromycin, Itraconazole, Ritonavir)
VII. Resources
- Alfuzosin Extended Release (DailyMed)
VIII. References
- Hamilton (2020) Tarascon Pharmacopoeia, Jones and Bartlett, Boston
- Nachawati (2022) Alpha Blockers, StatPearls, Treasure Island, FL, accessed 12/25/2022