II. Indications

III. Mechanism

  1. See ACE Inhibitor
  2. Non-sulfhydryl Angiotensin Converting Enzyme (ACE) inhibitor
  3. Perindopril is a prodrug, converted to its active form Perindoprilat via hydrolysis

IV. Dosing

  1. Adequate 24 hour Blood Pressure control may require twice daily dosing
  2. Hypertension
    1. Start 4 mg orally daily or divided twice daily
      1. Start at 2 mg/day in renal dysfunction or concurrent Diuretic use
    2. Target 4 to 8 mg/day
  3. Coronary Artery Disease secondary prevention
    1. Start 4 mg orally daily for 2 weeks
    2. May increase after 2 weeks to 8 mg/day
  4. Congestive Heart Failure (not FDA approved)
    1. Start 2 mg orally daily
    2. Maximum 16 mg/day
  5. Maximum 16 mg/day

V. Supplied

  1. Available as generic unscored tablets (2, 4, 8 mg)

VI. Metabolism

  1. Primarily renal metabolism

VII. Adverse Effects

VIII. Safety

  1. See ACE Inhibitor
  2. Pregnancy Category X
  3. Avoid in Lactation

X. References

  1. (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

Images: Related links to external sites (from Bing)

Related Studies

Cost: Medications

perindopril (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
PERINDOPRIL ERBUMINE 4 MG TAB Generic $0.47 each
PERINDOPRIL ERBUMINE 8 MG TAB Generic $0.50 each

Ontology: Perindopril (C0136123)

Definition (NCI) A non-sulfhydryl angiotensin converting enzyme (ACE) inhibitor with antihypertensive activity. Upon hydrolysis, perindopril is converted to its active form perindoprilat, inhibiting ACE and the conversion of angiotensin I to angiotensin II; consequently, angiotensin II-mediated vasoconstriction and angiotensin II-stimulated aldosterone secretion from the adrenal cortex are inhibited and diuresis and natriuresis ensue.
Definition (MSH) An angiotensin-converting enzyme inhibitor. It is used in patients with hypertension and heart failure.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D020913
SnomedCT 350606002, 129486004, 372916001
English perindopril, Perindopril, 1H-Indole-2-carboxylic acid, 1-(2-((1-(ethoxycarbonyl)butyl)amino)-1-oxopropyl)octahydro-, Pirindopril, (2S,3aS,7aS)-1-((S)-N-((S)-1-Carboxybutyl)alanyl)hexahydro-2-indolinecarboxylic Acid, 1-ethyl Ester, Perindopril [Chemical/Ingredient], pirindopril, PERINDOPRIL, Perindopril (product), Perindopril (substance)
Swedish Perindopril
Czech perindopril
Finnish Perindopriili
Russian PERINDOPRIL, ПЕРИНДОПРИЛ
Japanese ペリンドプリル
Spanish perindopril (producto), perindoprilo (producto), perindoprilo, perindopril (sustancia), perindoprilo (sustancia), perindopril, Perindopril
Polish Peryndopryl
French Périndopril
German Perindopril
Italian Perindopril
Portuguese Perindopril

Ontology: Aceon (C0875950)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Aceon, aceon