II. Indications

  1. Hyperlipidemia adjunctive management (rare use)

III. Contraindications

IV. Mechanism

  1. See Bile Acid Sequestrant
  2. Binds bile salts
    1. Results in insoluble complexes that are excreted in the stool

V. Dosing: Adult

  1. Tablets (1 gram each)
    1. Start 2 grams orally twice daily with a 6 to 8 ounces of liquid
    2. Maximum: 16 grams/day
  2. Granules (5 grams per 7.5 grams powder)
    1. Start 5 grams orally twice daily in 90 ml non-carbonated liquid
    2. Titrate in 5 gram increments every 1 to 2 months
    3. Maximum: 30 g/day

VI. Dosing: Child

  1. Not FDA approved in children
  2. Start 125 to 250 mg/kg/day orally divided 2 to 4 times daily up to 10 to 20 grams/day

VII. Drug Interactions

  1. See Bile Acid Sequestrant
  2. Take other medications at least 1 hour before 4 to 6 hours after Colestipol
  3. Take with water or orange juice before meals

VIII. Efficacy

IX. Adverse Effects

X. Safety

  1. Pregnancy Category B
  2. Considered Safe in Lactation

XI. Metabolism

  1. Not absorbed

XIII. References

  1. (2022) Non-StatinLipid Lowering Agents, Presc Lett, Resource #380202
  2. (2022) Med Lett Drugs Ther 64(1659): 145-52
  3. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  4. (2000) Med Lett Drugs Ther 42:102-4 [PubMed]

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Related Studies

Cost: Medications

colestipol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
COLESTIPOL HCL 1 GM TABLET Generic $0.79 each
COLESTIPOL HCL GRANULES PACKET Generic $2.79 each
colestid (on 1/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
COLESTID 1 GM TABLET Generic $0.79 each

Ontology: Colestipol (C0009279)

Definition (NCI) A positively charged, non-digestible, triamine and epoxypropane copolymer anion-exchange resin that binds to bile acids in the intestine to form an insoluble complex, which is excreted in the feces.
Definition (MSH) Highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic. It may also may reduce triglyceride levels.
Definition (CSP) highly crosslinked and insoluble basic anion exchange resin used as anticholesteremic, it may also may reduce triglyceride levels.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D003084
SnomedCT 372811005, 66971004
English Colestipol, colestipol, Colestipol [Chemical/Ingredient], COLESTIPOL, Colestipol (product), Colestipol (substance)
Swedish Kolestipol
Czech kolestipol
Finnish Kolestipoli
Russian KOLESTIPOL, КОЛЕСТИПОЛ
Japanese コレスチポール
Polish Kolestipol
Norwegian Kolestipol
Spanish colestipol (producto), colestipol (sustancia), colestipol, Colestipol
French Colestipol
German Colestipol
Italian Colestipolo
Portuguese Colestipol