Bisoprolol

Aka: Bisoprolol, Zebeta

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II. Mechanism

  1. See Beta Adrenergic ReceptorAntagonist
  2. Selective Beta Antagonist that primarily inhibits B1 activity by blocking B1 Receptors
    1. Reduces Myocardial Contractility, Blood Pressure, myocardial oxygen demand
    2. Also Antiarrhythmic and slows ventricular response in Atrial Fibrillation
  3. Contrast with non-selective Beta Blockers (e.g. Propranolol)
    1. Non-selective Beta Blockers also act at B2 Receptors (bronchoconstriction) and B3 Receptors (block lipolysis)

III. Adverse Effects

  1. See Beta Blocker

IV. Drug Interactions

  1. See Beta Blocker

V. Dosing

  1. Most cardioselective of Beta Blockers
  2. Start: 2.5 to 5 mg orally daily
  3. Maximum: 20 mg/day

VI. Resources

  1. Bisoprolol (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=4f20df45-3f9c-4a91-b394-e93a08111ec3

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