II. Mechanism

  1. See Beta Adrenergic ReceptorAntagonist
  2. Selective Beta Antagonist that primarily inhibits B1 activity by blocking B1 Receptors
    1. Reduces Myocardial Contractility, Blood Pressure, myocardial oxygen demand
    2. Also Antiarrhythmic and slows ventricular response in Atrial Fibrillation
  3. Contrast with non-selective Beta Blockers (e.g. Propranolol)
    1. Non-selective Beta Blockers also act at B2 Receptors (bronchoconstriction) and B3 Receptors (block lipolysis)

III. Adverse Effects

IV. Drug Interactions

V. Dosing

  1. Most cardioselective of Beta Blockers
  2. Start: 2.5 to 5 mg orally daily
  3. Maximum: 20 mg/day

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Related Studies

Cost: Medications

bisoprolol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
BISOPROLOL FUMARATE 10 MG TAB Generic $0.34 each
BISOPROLOL FUMARATE 5 MG TAB Generic $0.30 each
BISOPROLOL-HYDROCHLOROTHIAZIDE 10-6.25 MG TAB Generic $0.28 each
BISOPROLOL-HYDROCHLOROTHIAZIDE 2.5-6.25 MG TB Generic $0.29 each
BISOPROLOL-HYDROCHLOROTHIAZIDE 5-6.25 MG TAB Generic $0.28 each

Ontology: Bisoprolol (C0053799)

Definition (MSH) A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS.
Definition (NCI) A selective beta-1 adrenergic receptor antagonist with antihypertensive activity and devoid of intrinsic sympathomimetic activity. Bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, bisoprolol prevent the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D017298
SnomedCT 108547003, 386868003
English Bisoprolol, 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, Bisoprolol [Chemical/Ingredient], bisoprolol, BISOPROLOL, Bisoprolol (product), Bisoprolol (substance)
Swedish Bisoprolol
Czech bisoprolol
Finnish Bisoporoli
Russian BISOPROLOL, БИСОПРОЛОЛ
Japanese ビソプロロール
Polish Bisoprolol
Spanish bisoprolol (producto), bisoprolol (sustancia), bisoprolol, Bisoprolol
French Bisoprolol
German Bisoprolol
Italian Bisoprololo
Portuguese Bisoprolol

Ontology: Zebeta (C0724461)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Zebeta, zebeta