II. Mechanism
- See Beta Adrenergic ReceptorAntagonist
- Selective Beta Antagonist that primarily inhibits B1 activity by blocking B1 Receptors
- Reduces Myocardial Contractility, Blood Pressure, myocardial oxygen demand
- Also Antiarrhythmic and slows ventricular response in Atrial Fibrillation
- Contrast with non-selective Beta Blockers (e.g. Propranolol)
- Non-selective Beta Blockers also act at B2 Receptors (bronchoconstriction) and B3 Receptors (block lipolysis)
III. Adverse Effects
- See Beta Blocker
IV. Drug Interactions
- See Beta Blocker
V. Dosing
- Most cardioselective of Beta Blockers
- Start: 2.5 to 5 mg orally daily
- Maximum: 20 mg/day
VI. Resources
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Related Studies
bisoprolol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
BISOPROLOL FUMARATE 10 MG TAB | Generic | $0.34 each |
BISOPROLOL FUMARATE 5 MG TAB | Generic | $0.30 each |
BISOPROLOL-HYDROCHLOROTHIAZIDE 10-6.25 MG TAB | Generic | $0.28 each |
BISOPROLOL-HYDROCHLOROTHIAZIDE 2.5-6.25 MG TB | Generic | $0.29 each |
BISOPROLOL-HYDROCHLOROTHIAZIDE 5-6.25 MG TAB | Generic | $0.28 each |
Ontology: Bisoprolol (C0053799)
Definition (MSH) | A cardioselective beta-1 adrenergic blocker. It is effective in the management of HYPERTENSION and ANGINA PECTORIS. |
Definition (NCI) | A selective beta-1 adrenergic receptor antagonist with antihypertensive activity and devoid of intrinsic sympathomimetic activity. Bisoprolol selectively and competitively binds to and blocks beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, bisoprolol prevent the release of renin, a hormone secreted by the kidneys that causes constriction of blood vessels. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | D017298 |
SnomedCT | 108547003, 386868003 |
English | Bisoprolol, 2-Propanol, 1-(4-((2-(1-methylethoxy)ethoxy)methyl)phenoxy)-3-((1-methylethyl)amino)-, Bisoprolol [Chemical/Ingredient], bisoprolol, BISOPROLOL, Bisoprolol (product), Bisoprolol (substance) |
Swedish | Bisoprolol |
Czech | bisoprolol |
Finnish | Bisoporoli |
Russian | BISOPROLOL, БИСОПРОЛОЛ |
Japanese | ビソプロロール |
Polish | Bisoprolol |
Spanish | bisoprolol (producto), bisoprolol (sustancia), bisoprolol, Bisoprolol |
French | Bisoprolol |
German | Bisoprolol |
Italian | Bisoprololo |
Portuguese | Bisoprolol |
Ontology: Zebeta (C0724461)
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
English | Zebeta, zebeta |