II. Indications
- See ACE Inhibitor
III. Mechanism
- See ACE Inhibitor
- Synthetic Lysine derivative of Enalaprilat (active form of Enalapril)
-
Angiotensin Converting Enzyme (ACE) inhibitor
- Long acting ACE Inhibitor that may be dosed daily
- Other ACE Inhibitors (other than Enalapril) often are best dosed more than once daily
IV. Dosing: Adults
-
Hypertension
- Start 10 mg orally daily
- Target 20 to 40 mg/day
- Maximum 40 mg/day
-
Congestive Heart Failure (CHF)
- Start 2.5 to 5 mg orally daily
- Target 5 to 20 mg/day
- Maximum 40 mg/day
- Acute MI
- Start 5 mg orally daily for 2 days then increase to 10 mg orally daily
-
Diabetic Nephropathy
- Take 10 to 20 mg orally daily
-
Renal Dosing
- GFR 10-30
- Start 2.5 to 5 mg orally daily
- GFR <10 or on Hemodialysis
- Start 2.5 mg orally daily to start
- GFR 10-30
- Maximum 80 mg/day (but no added benefit above 40 mg/day)
V. Dosing: Children (age >=6 years)
- Contraindicated under age 6 years or GFR <30 ml/min
-
Hypertension
- Give 0.07 mg/kg up to 5 mg/day orally daily
VI. Supplied
- Available as generic/Prinivil scored tablets (10, 20 and 40 mg)
- Available as generic/Zestril unscored tabs (2.5, 5, 10, 20, 30 and 40 mg)
- Available as oral solution 1 mg/ml (Qbrelis)
VII. Metabolism
- Primarily renal excretion
VIII. Adverse Effects
- See ACE Inhibitor
IX. Safety
- See ACE Inhibitor
- Pregnancy Category X
- Avoid in Lactation
X. Resources
XI. References
- (2016) Presc Lett, Resource #321151, ACE Inhibitor Antihypertensive Dose Comparison
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 68-9
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
lisinopril (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
LISINOPRIL 10 MG TABLET | Generic | $0.02 each |
LISINOPRIL 2.5 MG TABLET | Generic | $0.02 each |
LISINOPRIL 20 MG TABLET | Generic | $0.02 each |
LISINOPRIL 30 MG TABLET | Generic | $0.06 each |
LISINOPRIL 40 MG TABLET | Generic | $0.05 each |
LISINOPRIL 5 MG TABLET | Generic | $0.01 each |
LISINOPRIL-HYDROCHLOROTHIAZIDE 10-12.5 MG TAB | Generic | $0.03 each |
LISINOPRIL-HYDROCHLOROTHIAZIDE 20-12.5 MG TAB | Generic | $0.05 each |
LISINOPRIL-HYDROCHLOROTHIAZIDE 20-25 MG TAB | Generic | $0.05 each |
qbrelis (on 1/1/2023 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
QBRELIS 1 MG/ML SOLUTION | $3.76 per ml |
Ontology: Lisinopril (C0065374)
Definition (CHV) | a drug used to treat hypertension and congestive heart failure |
Definition (CHV) | a drug used to treat hypertension and congestive heart failure |
Definition (NCI) | An orally bioavailable, long-acting angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity. Lisinopril, a synthetic peptide derivative, specifically and competitively inhibits ACE, which results in a decrease in the production of the potent vasoconstrictor angiotensin II and, so, diminished vasopressor activity. In addition, angiotensin II-stimulated aldosterone secretion by the adrenal cortex is decreased which results in a decrease in sodium and water retention and an increase in serum potassium. |
Definition (NCI_NCI-GLOSS) | A drug used to treat high blood pressure and certain heart conditions. It is also being studied in the prevention and treatment of side effects caused by some anticancer drugs. It blocks certain enzymes that cause blood vessels to constrict (narrow). It is a type of angiotensin-converting enzyme (ACE) inhibitor. |
Definition (MSH) | One of the ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACE inhibitors), orally active, that has been used in the treatment of hypertension and congestive heart failure. |
Definition (CSP) | lysine derivative of the active form of enalapril; an angiotensin converting enzyme inhibitor used in the treatment of hypertension. |
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | D017706 |
SnomedCT | 108575001, 386873009 |
LNC | LP171618-4 |
English | Lisinopril, Lysinopril, L-Proline, 1-(N2-(1-carboxy-3-phenylpropyl)-L-lysyl)-, dihydrate, (S)-, lisinopril, lisinopril (medication), LISINOPRIL, Lisinopril [Chemical/Ingredient], lysinopril, N2-[(1S)-1-Carboxy-3-phenylpropyl]-L-lysyl-L-proline, Dihydrate, Lisinopril (product), Lisinopril (substance) |
Swedish | Lisinopril |
Czech | lisinopril |
Finnish | Lisinopriili |
Russian | LIZINOPRIL, ЛИЗИНОПРИЛ |
Japanese | リシノプリル, リジノプリル |
Croatian | LIZINOPRIL |
Spanish | lisinoprilo, lisinopril (producto), lisinopril (sustancia), lisinopril, Lisinopril |
Polish | Lizynopryl |
French | Lisinopril |
German | Lisinopril |
Italian | Lisinopril |
Portuguese | Lisinopril |
Ontology: Zestril (C0678140)
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | D017706 |
English | zestril, Zestril |
Ontology: Prinivil (C0701176)
Concepts | Pharmacologic Substance (T121) , Amino Acid, Peptide, or Protein (T116) |
MSH | D017706 |
English | prinivil, Prinivil |