II. Efficacy
-
Lipid effects
- Decreases Triglycerides (20-50%)
- Increases LDL Cholesterol (10-15%)
- Decreases VLDL Cholesterol
- Increases HDL Cholesterol (10-15%)
- Outcome effects
- No effect on all cause mortality
- NNT to prevent one coronary event: 46-125
III. Adverse effects
- Gastrointestinal effects
- Gastrointestinal upset
- Abdominal Pain
- Higher rate of Gastrointestinal Disease
- Cholecystitis (increased risk by 2-3%)
- Appendicitis
- Miscellaneous
- Rash
- Renal dysfunction (rare)
- Myopathy (rare)
IV. Drug Interactions
- May potentiate effects of:
- Coumadin
- Oral Hypoglycemic Agents
V. Contraindications
VI. Preparations
- Gemfibrozil (Lopid)
- Dose: 600 mg bid ($75/month)
- Fenofibrate (Tricor)
- Less likely to cause Rhabdomyolysis with Statin
- Fenofibrate (Trilipix)
- Rebranded version of Tricor in time for generic Fenofibrate release in 2011
- Clofibrate
- Discontinued in 2002
- Increased mortality from malignant and GI disease
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Related Studies
gemfibrozil (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
GEMFIBROZIL 600 MG TABLET | Generic | $0.09 each |
fenofibrate (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
FENOFIBRATE 130 MG CAPSULE | Generic | $2.94 each |
FENOFIBRATE 134 MG CAPSULE | Generic | $1.01 each |
FENOFIBRATE 145 MG TABLET | Generic | $0.58 each |
FENOFIBRATE 150 MG CAPSULE | Generic | $5.56 each |
FENOFIBRATE 160 MG TABLET | Generic | $0.52 each |
FENOFIBRATE 200 MG CAPSULE | Generic | $1.75 each |
FENOFIBRATE 43 MG CAPSULE | Generic | $1.14 each |
FENOFIBRATE 48 MG TABLET | Generic | $0.42 each |
FENOFIBRATE 50 MG CAPSULE | Generic | $2.31 each |
FENOFIBRATE 54 MG TABLET | Generic | $0.39 each |
FENOFIBRATE 67 MG CAPSULE | Generic | $0.62 each |
tricor (on 3/22/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
TRICOR 145 MG TABLET | Generic | $0.58 each |
TRICOR 48 MG TABLET | Generic | $0.42 each |
trilipix (on 3/8/2017 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
TRILIPIX DR 135 MG CAPSULE | Generic | $1.61 each |
TRILIPIX DR 45 MG CAPSULE | Generic | $0.89 each |