II. Indications
III. Contraindications
- Severe Liver Impairment
IV. Mechanism
- Third generation Beta Blocker (Beta-1 Selective) with vasodilatory properties (nitric oxide release)
- Unique vasodilator mechanism with nitric oxide release via Beta-3 Agonist activity
- Relaxes vascular Smooth Muscle resulting in vasodilation
- Contrast with Labetalol and Carvedilol which exert vasodilation via alpha-1 activity
V. Dosing
- Start: 5 mg orally daily
- Start at 2.5 mg in hepatic Impairment or CrCl <30 ml/min
- Maximum: 40 mg/day
VI. Adverse Effects
- See Beta Blocker
VII. Safety
- Pregnancy Category C
- Avoid in Lactation
VIII. Resources
IX. References
- (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
- (2020) Med Lett Drugs Ther 62(1598): 73-80
- Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
- Hamilton (2020) Tarascon Pocket Pharmacopoeia
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Related Studies
nebivolol (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
NEBIVOLOL 10 MG TABLET | Generic | $0.25 each |
NEBIVOLOL 2.5 MG TABLET | Generic | $0.19 each |
NEBIVOLOL 20 MG TABLET | Generic | $0.28 each |
NEBIVOLOL 5 MG TABLET | Generic | $0.24 each |
bystolic (on 1/14/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
BYSTOLIC 10 MG TABLET | Generic | $0.25 each |
BYSTOLIC 2.5 MG TABLET | Generic | $0.19 each |
BYSTOLIC 20 MG TABLET | Generic | $0.28 each |
BYSTOLIC 5 MG TABLET | Generic | $0.24 each |
Ontology: nebivolol (C0068475)
Definition (NCI) | A beta-1 adrenergic receptor antagonist with antihypertensive and vasodilatory activity. Nebivolol binds to and blocks the beta-1 adrenergic receptors in the heart, thereby decreasing cardiac contractility and rate. This leads to a reduction in cardiac output and lowers blood pressure. In addition, nebivolol potentiates nitric oxide (NO), thereby relaxing vascular smooth muscle and exerting a vasodilatory effect. |
Concepts | Pharmacologic Substance (T121) , Organic Chemical (T109) |
MSH | C052753 |
SnomedCT | 318638009, 395808005 |
English | nebivolol, alpha,alpha'-(iminobis(methylene))bis(6-fluoro-3,4-dihydro)-2H-1-benzopyran-2-methanol, nebivolol [Chemical/Ingredient], NEBIVOLOL, Nebivolol (product), Nebivolol (substance), Nebivolol |
Spanish | nebivolol (producto), nebivolol (sustancia), nebivolol |
Ontology: Bystolic (C1995642)
Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
English | Bystolic |