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Ontology:
Guanabenz
(C0018312)
Definition (MSH)
|
An alpha-2 selective adrenergic agonist used as an antihypertensive agent.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D006143
|
SnomedCT |
372867002, 82951001 |
English |
2,6-Dichlorobenzylideneaminoguanidine, Guanabenz, 2,6 Dichlorobenzylideneaminoguanidine, Hydrazinecarboximidamide, 2-((2,6-dichlorophenyl)methylene)-, guanabenz, Guanabenz [Chemical/Ingredient], GUANABENZ, Guanabenz (product), Guanabenz (substance) |
Swedish |
Guanabenz
|
Czech |
guanabenz
|
Finnish |
Guanabentsi
|
Russian |
GUANABENZ, ГУАНАБЕНЗ |
Japanese |
グアナベンツ, グアナベンズ |
Polish |
Guanabenz
|
Spanish |
guanabenz (producto), guanabenz (sustancia), guanabenz, Guanabenzo |
French |
Guanabenz
|
German |
Guanabenz
|
Italian |
Guanabenzo
|
Portuguese |
Guanabenzo
|
Ontology:
Wytensin
(C0018313)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D006143
|
English |
Wyeth-Ayerst of Guanabenz Acetate, Wyeth Ayerst of Guanabenz Acetate, Acetate Wyeth-Ayerst, Guanabenz, Guanabenz Acetate Wyeth-Ayerst, Wytensin |
Ontology:
Guanethidine
(C0018318)
Definition (MSH)
|
An antihypertensive agent that acts by inhibiting selectively transmission in post-ganglionic adrenergic nerves. It is believed to act mainly by preventing the release of norepinephrine at nerve endings and causes depletion of norepinephrine in peripheral sympathetic nerve terminals as well as in tissues.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D006145
|
SnomedCT |
387456007, 79305004 |
English |
Guanethidine, Octadine, Oktadin, ((2-Hexahydro-1(2H)-azocinyl)ethyl)guanidine, guanethidine, Guanidine, (2-(hexahydro-1(2H)-azocinyl)ethyl)-, guanethidines (medication), guanethidines, Octatensine, (2-(Octahydro-1-azocinyl)ethyl)guanidine, Guanethidine [Chemical/Ingredient], Guanethidine (product), Guanethidine (substance), GUANETHIDINE |
Swedish |
Guanetidin
|
Czech |
guanethidin
|
Finnish |
Guanetidiini
|
Russian |
GUANETIDIN, OKTADIN, ГУАНЕТИДИН, ОКТАДИН |
Japanese |
グアネチジン, 硫酸グアネチジン |
Polish |
Guanetydyna, Ismelina |
Spanish |
guanetidina (producto), guanetidina (sustancia), guanetidina, Guanetidina |
French |
Guanéthidine
|
German |
Guanethidin
|
Italian |
Guanetidina
|
Portuguese |
Guanetidina
|
Ontology:
Methyldopa
(C0025741)
Definition (NCI)
|
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is metabolized in the central nervous system. The antihypertensive action of methyldopa seems to be attributable to its conversion into alpha-methylnorepinephrine, which is a potent alpha-2 adrenergic agonist that binds to and stimulates potent central inhibitory alpha-2 adrenergic receptors. This results in a decrease in sympathetic outflow and decreased blood pressure.
|
Definition (MSH)
|
An alpha-2 adrenergic agonist that has both central and peripheral nervous system effects. Its primary clinical use is as an antihypertensive agent.
|
Concepts |
Pharmacologic Substance
(T121)
, Neuroreactive Substance or Biogenic Amine
(T124)
, Amino Acid, Peptide, or Protein
(T116)
|
MSH |
D008750
|
SnomedCT |
373542000, 84078002 |
LNC |
LP16200-5, MTHU016766 |
English |
Alphamethyldopa, alpha Methyl L Dopa, alpha Methyldopa, alpha-Methyl-L-Dopa, alpha-Methyldopa, methyldopa, L-Tyrosine, 3-hydroxy-alpha-methyl-, 3-Hydroxy-alpha-methyl-L-tyrosine, L-2-Amino-2-methyl-3-(3,4-dihydroxyphenyl)propionic Acid, Levo-3-(3,4-Dihydroxyphenyl)-2-methylalanine, O methyl DOPA, methyldopa (medication), Methyldopa [Chemical/Ingredient], alphamethyldopa, alpha-methyldopa, alpha methyldopa, METHYLDOPA, Methyldopa, Alpha methyldopa, Methyldopa (product), Methyldopa (substance) |
Swedish |
Metyldopa
|
Czech |
methyldopa
|
Finnish |
Metyylidopa
|
Russian |
AL'FA-METILDOFA, METILDOPA, METILDOFA, METILDOPAT, АЛЬФА-МЕТИЛДОФА, МЕТИЛДОПА, МЕТИЛДОПАТ, МЕТИЛДОФА |
Japanese |
α-メチルドーパ, メチルドパ, メチルドーパ, アルファ-メチルドーパ |
Spanish |
alfa-Metildopa, metildopa (producto), metildopa (sustancia), metildopato, metildopa, Metildopa |
French |
alpha-Méthyldopa, alpha-L-Méthyldopa, Méthyldopa |
Croatian |
METILDOPA
|
Polish |
Metylodopa
|
German |
Alphamethyldopa, Methyldopa |
Italian |
Metildopa
|
Portuguese |
alfa-Metildopa, Metildopa |
Ontology:
Reserpine
(C0035179)
Definition (NCI)
|
An alkaloid, derived from the roots of Rauwolfia serpentine and vomitoria, and an adrenergic uptake inhibitor with antihypertensive effects. Reserpine is lipid soluble and can penetrate blood-brain barrier. This agent binds and inhibits catecholamine pump on the storage vesicles in central and peripheral adrenergic neurons, thereby inhibiting the uptake of norepinephrine, dopamine serotonin into presynaptic storage vesicles. This results in catecholamines and serotonin lingering in the cytoplasm where they are destroyed by intraneuronal monoamine oxidase, thereby causing the depletion of catecholamine and serotonin stores in central and peripheral nerve terminals. Depletion results in a lack of active transmitter discharge from nerve endings upon nerve depolarization, and consequently leads to a decreased heart rate and decreased arterial blood pressure as well as sedative effects.
|
Definition (MSH)
|
An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.
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Definition (CSP)
|
alkaloid isolated from the root of Rauwolfia species, used as an antihypertensive and sedative.
|
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D012110
|
SnomedCT |
363523003, 387447004, 78379001 |
English |
Reserpine, Yohimban-16-carboxylic acid, 11,17-dimethoxy-18-((3,4,5-trimethoxybenzoyl)oxy)-, methyl ester, (3beta,16beta,17alpha,18beta,20alpha)-, (3beta,16beta,17alpha,18beta,20alpha)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic Acid Methyl Ester, reserpine, reserpine (medication), Reserpine [Chemical/Ingredient], RESERPINE, Reserpine - chemical, Reserpine - chemical (substance), Reserpine (product), Reserpine (substance) |
Swedish |
Reserpin
|
Czech |
reserpin
|
Finnish |
Reserpiini
|
Russian |
REZERPIN, RESTSINNAMIN, SIRINGOPIN, SIROSINGOPIN, РЕЗЕРПИН, РЕСЦИННАМИН, СИРИНГОПИН, СИРОСИНГОПИН |
Japanese |
レセルピン
|
Croatian |
REZERPIN
|
Polish |
Rezerpina, Serpazyl |
Spanish |
reserpina - sustancia química (sustancia), reserpina - sustancia química, reserpina (producto), reserpina (sustancia), reserpina, Reserpina |
French |
Réserpine
|
German |
Reserpin
|
Italian |
Reserpina
|
Portuguese |
Reserpina
|
Ontology:
guanadrel
(C0061938)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
C004945
|
SnomedCT |
372820001, 69204002 |
English |
(1,4-dioxaspiro(4.5)dec-2-ylmethyl)guanidine, guanadrel, guanadrel [Chemical/Ingredient], Guanadrel, Guanadrel (product), Guanadrel (substance), GUANADREL |
Spanish |
guanadrel (producto), guanadrel (sustancia), guanadrel |
Ontology:
Central alpha-adrenoceptor agonist
(C0360167)
Concepts |
Pharmacologic Substance
(T121)
|
SnomedCT |
349933002, 372623002 |
English |
Central alpha-adrenocep agon., Central alpha-adrenoceptor agonist, Central alpha-adrenoceptor agonist (product), Central alpha-adrenoceptor agonist (substance) |
Spanish |
agonista central alfa adrenérgico (producto), agonista central alfa adrenérgico (sustancia), agonista central alfa adrenérgico, agonista de adrenorreceptor alfa central (sustancia), agonista de adrenorreceptor alfa central |
Ontology:
Aldomet
(C0591055)
Concepts |
Pharmacologic Substance
(T121)
, Amino Acid, Peptide, or Protein
(T116)
|
MSH |
D008750
|
English |
aldomet, Aldomet, Biopat Brand of Methyldopa, Cahill May Roberts Brand of Methyldopa, Merck Brand of Methyldopa, Merck Sharp & Dohme Brand of Methyldopa, Methyldopa Biopat Brand, Methyldopa Merck Brand |
Ontology:
Ismelin
(C0701214)
Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
|
MSH |
D006145
|
English |
guanethidine sulfate (Ismelin), Ismelin |
Ontology:
Hylorel
(C0720982)
Concepts |
Organic Chemical
(T109)
, Pharmacologic Substance
(T121)
|
MSH |
C004945
|
English |
Hylorel, Celltech brand of guanadrel sulfate |
Ontology:
Serpasil
(C0729168)
Concepts |
Organic Chemical
(T109)
, Pharmacologic Substance
(T121)
|
MSH |
D012110
|
English |
Serpasil
|