II. Indications

III. Mechanism

  1. See Beta Adrenergic ReceptorAntagonist
  2. Selective Beta Antagonist that primarily inhibits B1 activity by blocking B1 Receptors
    1. Reduces Myocardial Contractility, Blood Pressure, myocardial oxygen demand
    2. Also Antiarrhythmic and slows ventricular response in Atrial Fibrillation
  3. Contrast with non-selective Beta Blockers (e.g. Propranolol)
    1. Non-selective Beta Blockers also act at B2 Receptors (bronchoconstriction) and B3 Receptors (block lipolysis)

IV. Adverse Effects

V. Drug Interactions

VI. Metabolism

  1. Bioavailability 90%
    1. Low first pass hepatic metabolism
  2. Primarily excreted by the liver
  3. Lipophilic

VII. Dosing

  1. Start: 10 mg orally daily
    1. Start at 5 mg in older patients or with renal Impairment
  2. Maximum: 20 mg/day

VIII. Safety

  1. Pregnancy Category C
  2. Unknown Safety in Lactation

X. References

  1. (2019) Presc Lett, Resource #350503, Comparison of Oral Beta Blockers
  2. (2020) Med Lett Drugs Ther 62(1598): 73-80
  3. Olson (2020) Clinical Pharmacology, Medmaster Miami, p. 66-7
  4. Hamilton (2020) Tarascon Pocket Pharmacopoeia

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betaxolol (on 6/22/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
BETAXOLOL 10 MG TABLET Generic $0.58 each
BETAXOLOL HCL 0.5% EYE DROP Generic $9.32 per ml