II. Indications
- Activity
- Broad Gram Negative and Gram Positive coverage
- May cover organisms resistant to other Antibiotics
- Methicillin-resistant Staphylococcus Aureus
- Vancomycin-resistant Enterococcus species
- Acinetobacter baumannii
- ESBL Gram-Negative Bacteria
- Conditions
- Community Acquired Pneumonia
- Avoid in Hospital Acquired Pneumonia
- Avoid in Ventilator Associated Pneumonia
- Complicated Intraabdominal Infections
- Avoid in intestinal perforation
- Complicated Skin Infections
- Avoid in Diabetic Foot Infections
- Community Acquired Pneumonia
III. Contraindications
- Pregnancy
- Children age <8 years
- Relatively contraindicated as well in age <17 years
IV. Mechanism
- See Tetracyclines
- Broad-spectrum glycylcycline Antibiotic derived from Tetracycline
V. Dosing: Adult
- Reconstituted Intravenous Fluid should have a yellow orange coloration
- Load: 100 mg IV infused over 30 to 60 minutes
- Next: 50 mg IV infused over 30 to 60 minutes every 12 hours
- Decrease dose to 25 mg IV in Child-Pugh C severe liver disease
VI. Dosing: Child
- Avoid in children in general unless no other alternative agent
- Absolutely contraindicated in children <8 years old
- Age 8 to 11 years
- Give 1.2 mg/kg (up to 50 mg) IV every 12 hours
- Age 12 to 17 years
- Give 50 mg IV every 12 hours
VII. Adverse Effects
- See Tetracyclines
- Nausea
VIII. Safety
- Pregnancy Category D
- Unknown safety in Lactation
IX. Drug Interactions
-
Warfarin
- May increase INR
X. Resources
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Related Studies
Definition (NCI) | A broad-spectrum glycylcycline antibiotic derived from tetracycline. Tigecycline binds to the 30S ribosomal subunit, thereby interfering with the binding of aminoacyl-tRNA to the mRNA-ribosome complex. This prevents the incorporation of amino acid residues into the elongating peptide chain, inhibiting protein synthesis and eventually bacterial cell growth. |
Concepts | Organic Chemical (T109) , Antibiotic (T195) |
MSH | C119092 |
SnomedCT | 418631002, 418313005 |
LNC | LP36048-4, MTHU019077 |
Spanish | tigeciclina (producto), tigeciclina (sustancia), tigeciclina |
English | tigecycline (medication), TIGECYCLINE, tigecycline [Chemical/Ingredient], tigecycline, 9-(tert-butylglycylamido)minocycline, TBG-MINO, Tigecycline (product), Tigecycline (substance), Tigecycline |