III. Contraindications

  1. Staphylococcus Aureus infection (poor activity)

V. Medications

  1. Capsules: 400 mg
  2. Chewable Tablets: 100 or 200 mg (contain Phenylalanine)
  3. Suspension: 100 or 200 mg/5ml and 500 mg/5 ml
    1. Stable at room Temperature for 2 weeks

VI. Dosing

  1. Adult (or child age >13 years, weight > 45 to 50 kg)
    1. Standard Dosing
      1. Take 400 mg orally divided once daily
    2. Gonorrhea
      1. Take 400 mg orally for single dose
  2. Child (age <13 years or weight < 45 to 50 kg)
    1. Standard Dosing
      1. Give 8 mg/kg/day divided daily to twice daily
    2. Febrile Urinary Tract Infection
      1. Give 16 mg/kg orally on day 1, then 8 mg/kg/day daily for 14 days
  3. Renal Dosing
    1. eGFR 21 to 60 ml/min (or Hemodialysis): Decrease usual dose to 75%
    2. eGFR <20 ml/min (or Peritoneal Dialysis): Decrease usual dose to 50%

VII. Safety

  1. Pregnancy Category B
  2. Safe in Lactation

VIII. Drug Interactions

  1. Warfarin
    1. Cefixime may increase INR
  2. Carbamazepine
    1. Cefixime may increase Carbamazepine levels

X. References

  1. Hamilton (2020) Tarascon Pocket Pharmacopoeia
  2. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins

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Related Studies

Cost: Medications

cefixime (on 2/22/2023 at Medicaid.Gov Survey of pharmacy drug pricing)
CEFIXIME 200 MG/5 ML SUSP Generic $4.86 per ml
CEFIXIME 400 MG CAPSULE Generic $10.76 each

Ontology: Cefixime (C0060400)

Definition (NCI_NCI-GLOSS) An antibiotic drug used to treat infection. It belongs to the family of drugs called cephalosporins.
Definition (NCI) A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins.
Definition (MSH) A third-generation cephalosporin antibiotic that is stable to hydrolysis by beta-lactamases.
Definition (PDQ) A broad-spectrum, third-generation cephalosporin antibiotic derived semisynthetically from the marine fungus Cephalosporium acremonium with antibacterial activity. As does penicillin, the beta-lactam antibiotic cefixime inhibits bacterial cell wall synthesis by disrupting peptidoglycan synthesis, resulting in a reduction in bacterial cell wall stability and bacterial cell lysis. Stable in the presence of a variety of beta-lactamases, this agent is more active against gram-negative bacteria and less active against gram-positive bacteria compared to second-generation cephalosporins. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37809&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37809&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1100" NCI Thesaurus)
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D020682
SnomedCT 387536009, 96052006
LNC LP17701-1, MTHU005580
English cefixime, cefixime (medication), 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylicacid,7-(((2-amino-4-thiazolyl)((carboxymethoxy)imino)acetyl)amino)3-ethenyl-8-oxo-, trihydrate, (6R-(6alpha,7beta(Z)))-, Cefixime [Chemical/Ingredient], CEFIXIME, Trihydrate, Cefixime, Cefixime Trihydrate, Cefixime (product), Cefixime (substance), Cefixime
Swedish Cefixim
Czech cefixim
Finnish Kefiksiimi
Russian TSEFIKSIM, ЦЕФИКСИМ
Japanese セフィキシム
Polish Cefiksym
Spanish cefixima (producto), cefixima (sustancia), cefixima, Cefixima
French Céfixime
German Cefixim
Italian Cefixima
Portuguese Cefixima