II. Indications

  1. See First Generation Cephalosporin
  2. Generic and similar efficacy to Cephalexin
    1. Ease of twice daily dosing instead of four times daily
  3. Specific Indications
    1. Skin and Soft Tissue Infection
    2. Streptococcal Pharyngitis
    3. Simple Urinary Tract Infections (Acute Cystitis)
    4. Not indicated for Otitis Media (inadequate coverage due to resistance)

III. Mechanism

IV. Dosing

  1. May take with or without food
  2. Adult
    1. Give 1 g orally twice daily
    2. May decrease to 500 mg orally twice daily in simple UTI and Streptococcal Pharyngitis
  3. Child (age > 6 weeks)
    1. Give 30 mg/kg/day orally divided twice daily
  4. Renal Dosing (Adult)
    1. eGFR 26 to 50 ml/min
      1. First dose 1 gram orally
      2. Then 500 mg orally every 12 hours
    2. eGFR 11 to 25 ml/min
      1. Take 500 mg every 24 hours
    3. eGFR <10 ml/min
      1. Take 500 mg every 36 hours

V. Adverse Effects

  1. Allergic Reaction
    1. Cross reactivity with Amoxicillin

VI. Safety

  1. Pregnancy Category B (All Trimesters)
  2. Safe in Lactation

VIII. References

  1. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins

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Related Studies

Cost: Medications

cefadroxil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CEFADROXIL 1 GM TABLET Generic $2.73 each
CEFADROXIL 250 MG/5 ML SUSP Generic $0.21 per ml
CEFADROXIL 500 MG CAPSULE Generic $0.27 each
CEFADROXIL 500 MG/5 ML SUSP Generic $0.30 per ml

Ontology: Cefadroxil (C0007538)

Definition (NCI) A semi-synthetic, beta-lactam, first-generation cephalosporin antibiotic with bactericidal activity. Cefadroxil binds to and inactivates penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. PBPs are enzymes involved in the terminal stages of assembling the bacterial cell wall and in reshaping the cell wall during growth and division. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This results in the weakening of the bacterial cell wall and causes cell lysis.
Definition (MSH) Long-acting, broad-spectrum, water-soluble, CEPHALEXIN derivative.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D002434
SnomedCT 13414000, 372651006
LNC LP17101-4, MTHU005578
English 4 Hydroxycephalexin, 4-Hydroxycephalexin, Cefadroxil, Cephadroxyl, 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-((amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-, (6R-(6alpha,7beta(R*)))-, (6R,7R)-7-(((2R)-Amino(4-hydroxyphenyl)acetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic Acid, cefadroxil, CEFADROXIL, Cefadroxil [Chemical/Ingredient], cephadroxyl, Cefadroxil Monohydrate, Cefadroxil (product), Cefadroxil (substance)
Swedish Cefadroxil
Czech cefadroxil
Finnish Kefadroksiili
Italian 4-Idrossi cefalessina, Cefadrossil
Russian TSEFADROKSIL, ЦЕФАДРОКСИЛ
Japanese セファドロキシル
Polish Cefadroksyl
Spanish cefadroxilo (producto), cefadroxilo (sustancia), cefadroxilo, Cefadroxilo
French Céfadroxil
German Cefadroxil
Portuguese Cefadroxila

Ontology: Duricef (C0701890)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH D002434
English duricef, Duricef