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Ontology:
artesunate
(C0052432)
Definition (NCI)
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A water-soluble, semi-synthetic derivative of the sesquiterpine lactone artemisinin with anti-malarial, anti-shistosomiasis, antiviral, and potential anti-neoplastic activities. Upon hydrolysis of artesunate's active endoperoxide bridge moiety by liberated heme in parasite-infected red blood cells, reactive oxygen species and carbon-centered radicals form, which have been shown to damage and kill parasitic organisms. Additionally, in vitro studies demonstrate that this agent induces DNA breakage in a dose-dependent manner. Artesunate has also been shown to stimulate cell differentiation, arrest the cell cycle in the G1 and G2/M phases, inhibit cell proliferation, and induce apoptosis through mitochondrial and caspase signaling pathways. Artemisinin is isolated from the plant Artemisia annua.
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Concepts |
Pharmacologic Substance
(T121)
, Organic Chemical
(T109)
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MSH |
C039726
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SnomedCT |
432410005, 432555000 |
English |
ARTESUNATE, Artesunate (substance), Artesunate (product), Artesunate, succinyl dihydroartemisinin, dihydroartemisinine-12-alpha-succinate, artesunate, artesunate [Chemical/Ingredient], 4-oxo-4-{[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano[4,3-j]-1,2-benzodioxepin-10-yl]oxy}butanoic acid |
Spanish |
artesunato (producto), artesunato (sustancia), artesunato |