III. Medications

  1. Tablets: 250 or 500 mg
  2. Suspension 125 or 250 mg/5 ml

IV. Dosing

  1. Adult
    1. Typical dosing
      1. Take 250 to 500 mg orally daily to twice daily
    2. Streptococcal Pharyngitis (second-line)
      1. Take 500 mg orally daily for 10 days
  2. Child
    1. Otitis Media
      1. GIve 15 mg/kg/dose orally twice daily
    2. Streptococcal Pharyngitis (second-line)
      1. Give 7.5 mg/kg/dose orally twice daily for 10 days
  3. Renal Dosing
    1. eGFR <30 ml/min: Give 50% of typical dose

V. Adverse Effects

  1. Allergic Reaction risk
    1. Cross reaction with Amoxicillin Allergy
  2. Gastrointestinal (oral formulations, mild)
    1. Nausea or Vomiting
    2. Diarrhea

VI. Safety

  1. Pregnancy Category B
  2. Safe in Lactation

VIII. References

  1. (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
  2. Wiseman (1993) Drugs 45(2):295-317 +PMID: 7681376 [PubMed]

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Related Studies

Cost: Medications

cefprozil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CEFPROZIL 125 MG/5 ML SUSP Generic $0.24 per ml
CEFPROZIL 250 MG TABLET Generic $0.44 each
CEFPROZIL 250 MG/5 ML SUSP Generic $0.32 per ml
CEFPROZIL 500 MG TABLET Generic $0.86 each

Ontology: cefprozil (C0053882)

Definition (NCI) A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefprozil's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefprozil inhibits bacterial septum and cell wall synthesis formation.
Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C052018
SnomedCT 387538005, 96054007
LNC LP15219-6, MTHU001907
English cefprozil, CEFPROZIL, cefprozil (medication), 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-, cefprozil [Chemical/Ingredient], Cefprozil, Cefprozil (product), Cefprozil (substance)
Spanish cefprozilo (producto), cefprozilo, cefprozilo (sustancia), cefprozil, cefprozil (producto), cefprozil (sustancia)

Ontology: Cefzil (C0728743)

Concepts Antibiotic (T195) , Organic Chemical (T109)
MSH C052018
English Cefzil, cefzil, Bristol-Myers Squibb brand of cefprozil