II. Indications
III. Medications
- Tablets: 250 or 500 mg
- Suspension 125 or 250 mg/5 ml
IV. Dosing
- Adult
- Typical dosing
- Take 250 to 500 mg orally daily to twice daily
- Streptococcal Pharyngitis (second-line)
- Take 500 mg orally daily for 10 days
- Typical dosing
- Child
- Otitis Media
- GIve 15 mg/kg/dose orally twice daily
- Streptococcal Pharyngitis (second-line)
- Give 7.5 mg/kg/dose orally twice daily for 10 days
- Otitis Media
-
Renal Dosing
- eGFR <30 ml/min: Give 50% of typical dose
V. Adverse Effects
-
Allergic Reaction risk
- Cross reaction with Amoxicillin Allergy
- Gastrointestinal (oral formulations, mild)
VI. Safety
- Pregnancy Category B
- Safe in Lactation
VII. Resources
VIII. References
- (2012) Presc Lett, Resource #280706, Comparison of Cephalosporins
- Wiseman (1993) Drugs 45(2):295-317 +PMID: 7681376 [PubMed]
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Related Studies
cefprozil (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing) | ||
CEFPROZIL 125 MG/5 ML SUSP | Generic | $0.24 per ml |
CEFPROZIL 250 MG TABLET | Generic | $0.44 each |
CEFPROZIL 250 MG/5 ML SUSP | Generic | $0.32 per ml |
CEFPROZIL 500 MG TABLET | Generic | $0.86 each |
Ontology: cefprozil (C0053882)
Definition (NCI) | A semi-synthetic cephalosporin and a beta-lactam antibiotic with bactericidal activity. Cefprozil's effect is dependent on its binding to penicillin-binding proteins (PBPs) located in the bacterial cytoplasmic membrane. Binding results in the inhibition of the transpeptidase enzymes, thereby preventing cross-linking of the pentaglycine bridge with the fourth residue of the pentapeptide and interrupting consequent synthesis of peptidoglycan chains. As a result, cefprozil inhibits bacterial septum and cell wall synthesis formation. |
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C052018 |
SnomedCT | 387538005, 96054007 |
LNC | LP15219-6, MTHU001907 |
English | cefprozil, CEFPROZIL, cefprozil (medication), 5-Thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7-(((2R)-amino(4-hydroxyphenyl)acetyl)amino)-8-oxo-3-(1-propenyl)-, (6R,7R)-, cefprozil [Chemical/Ingredient], Cefprozil, Cefprozil (product), Cefprozil (substance) |
Spanish | cefprozilo (producto), cefprozilo, cefprozilo (sustancia), cefprozil, cefprozil (producto), cefprozil (sustancia) |
Ontology: Cefzil (C0728743)
Concepts | Antibiotic (T195) , Organic Chemical (T109) |
MSH | C052018 |
English | Cefzil, cefzil, Bristol-Myers Squibb brand of cefprozil |