Clotrimazole

Aka: Clotrimazole, Lotrimin AF, Mycelex, Clotrimaderm, Gyn-Lotrimin, Mycelex G

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II. Indications

  1. Dermatophyte Infection
    1. Tinea Pedis
    2. Tinea Cruris
    3. Tinea Corporis
    4. Tinea Versicolor
  2. Superficial Candida Infection
    1. Cutaneous Candidiasis
    2. Oral Candidiasis (Thrush)
    3. Yeast Vaginitis
  3. Other off-label uses
    1. Seborrheic Dermatitis

III. Mechanism

  1. As with other azoles, inhibits the synthesis of ergosterol (key component of fungal cell wall)
    1. Blocks sterol 14-a-dimethylase (microsomal Cytochrome P450-dependent enzyme)

IV. Medications

  1. Precautions
    1. Bayer Healthcare uses the Lotrimin brand name to apply to various Antifungals (e.g. Miconazole, Butenafine)
  2. Oral Candidiasis
    1. Clotrimazole 10 mg troche (Mycelex)
  3. Topical Antifungals
    1. Clotrimazole Cream 1%
    2. Clotrimazole Solution 1%
  4. Vaginal Antifungals
    1. Clotrimazole 1 to 2% vaginal creams
    2. Clotrimazole 100, 200 and 500 mg vaginal tablets

V. Dosing

  1. Oral Candidiasis (Thrush) in Adults and children over age 3 years
    1. Treatment
      1. Dissolve one troche (10 mg) slowly in mouth five times daily for 14 days
    2. Prevention in Immunocompromised patients
      1. Dissolve one troche (10 mg) slowly in mouth three times daily
      2. Continue until Chemotherapy or high dose Corticosteroid course is completed
  2. Topical (Dermatophyte Infection or Superficial Candida infection) for adults and children
    1. Apply twice daily to affected area
  3. Yeast Vaginitis (Gyn-Lotrimin, Mycelex G)
    1. Clotrimazole 1% cream at bedtime for 7 days
    2. Clotrimazole 2% cream at bedtime for 3 days
    3. Clotrimazole 200 mg vaginal tab PV at at bedtime for 3 days
    4. Clotrimazole 100 mg vaginal tab PV at bedtime for 7 days
    5. Clotrimazole 500 mg vaginal tab PV at bedtime for 1 dose

VI. Adverse Effects: Oral Dosing for Thrush

  1. May raise Liver Function Tests
  2. Gastrointestinal Side effects

VII. Safety

  1. Pregnancy Category C orally (Category B topically)
  2. Considered safe in Lactation

VIII. Resources

  1. Clotrimazole 1% Cream (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=b3b83f3f-9349-fb75-e053-2995a90acb65
  2. Clotrimazole Solution (DailyMed)
    1. https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=13a14d3c-bfce-42b5-8463-4ec69e94774e

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Related Studies

Cost: Medications

clotrimazole (on 12/21/2022 at Medicaid.Gov Survey of pharmacy drug pricing)
CLOTRIMAZOLE 1% SOLUTION Generic OTC $2.66 per ml
CLOTRIMAZOLE 1% TOPICAL CREAM Generic OTC $0.05 per gram
CLOTRIMAZOLE 1% VAGINAL CREAM Generic OTC $0.08 per gram
CLOTRIMAZOLE 10 MG TROCHE Generic $0.38 each
CLOTRIMAZOLE-3 2% CREAM Generic OTC $0.31 per gram
CLOTRIMAZOLE-BETAMETHASONE CRM Generic $0.23 per gram
CLOTRIMAZOLE-BETAMETHASONE LOT Generic $2.65 per ml
FPNotebook does not benefit financially from showing this medication data or their pharmacy links. This information is provided only to help medical providers and their patients see relative costs. Insurance plans negotiate lower medication prices with suppliers. Prices shown here are out of pocket, non-negotiated rates. See Needy Meds for financial assistance information. GoodRx is another tool for finding lower drug prices.

Ontology: Clotrimazole (C0009074)

Definition (NCI) A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis.
Definition (PDQ) A synthetic, imidazole derivate with broad-spectrum, antifungal activity. Clotrimazole inhibits biosynthesis of sterols, particularly ergosterol, an essential component of the fungal cell membrane, thereby damaging and affecting the permeability of the cell membrane. This results in leakage and loss of essential intracellular compounds, and eventually causes cell lysis. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39116&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39116&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C381" NCI Thesaurus)
Definition (MSH) An imidazole derivative with a broad spectrum of antimycotic activity. It inhibits biosynthesis of the sterol ergostol, an important component of fungal CELL MEMBRANES. Its action leads to increased membrane permeability and apparent disruption of enzyme systems bound to the membrane.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D003022
SnomedCT 332860008, 330922006, 387325003, 5797005
LNC LP14809-5, MTHU002025
English Klotrimazole, 1H-Imidazole, 1-((2-chlorophenyl)diphenylmethyl)-, Clotrimazole [ear], Clotrimazole [skin], 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole, clotrimazole, CLOT, CLOTRIMAZOLE, Clotrimazole [Chemical/Ingredient], Clotrimazole [skin] (product), Clotrimazole [ear] (product), Clotrimazole product, Clotrimazole (product), Clotrimazole (substance), Clotrimazole, Clotrimazole [ear] (substance), Clotrimazole [skin] (substance)
Swedish Klotrimazol
Czech klotrimazol
Finnish Klotrimatsoli
Russian KLOTRIMAZOL, KANESTEN, КАНЕСТЕН, КЛОТРИМАЗОЛ
Japanese クロトリマゾール
Polish Klotrimazol, Klotrymazol
Croatian KLOTRIMAZOL
Norwegian Klotrimazol
Spanish clotrimazol (uso ótico) (producto), clotrimazol (uso ótico), clotrimazol (uso dermatológico) (producto), clotrimazol (uso dermatológico), clotrimazol (oído) (producto), clotrimazol (oído), clotrimazol (piel) (producto), clotrimazol (piel), clotrimazol (producto), clotrimazol (sustancia), clotrimazol, Clotrimazol
French Clotrimazole
German Clotrimazol
Italian Clotrimazolo
Portuguese Clotrimazol
Derived from the NIH UMLS (Unified Medical Language System)

Related Topics in Pharmacology

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