II. Epidemiology
-
Prevalence
- General population: 1-3%
- Immunocompromised: >34%
- Gender
- More common in men
- Age (multimodal)
- Age 2 to 12 months (Cradle Cap, self-limited and resolves)
- Adolescent and young adult
- Older adult
III. Pathophysiology
- Primary Factors
- Sebum overproduction by Sebaceous Glands (Seborrhea)
- Malassezia yeast overgrowth (see below)
- Disrupted epidermal skin barrier
- Dysregulated inflammatory response
- Associated with fungal overgrowth
- Normal skin colonization with the Fungus Malassezia species (Malassezia furfur, Malassezia ovalis)
- Malassezia invade Stratum Corneum in Seborrheic Dermatitis
- Release Lipases that in turn result in free Fatty Acid formation
- Free Fatty Acids allow for increased Malassezia growth and cause the localized skin inflammation
- Stratum Corneum proliferates in response to inflammation and results in Scaling
- Stratum Corneum is also impaired as a barrier allowing for further Malassezia invasion
- Dysregulated inflammatory response
IV. Causes
- Idiopathic (most cases)
V. Risk Factors
- Immunocompromised state (e.g. AIDS)
- Increased emotional stress
- Cold, dry environments
- Sun Exposure
VI. Associated Conditions
- Acquired Immunodeficiency Syndrome (AIDS)
- Nutritional deficiency
- Impaired essential Fatty Acid Metabolism
- Neurologic conditions
- Parkinsonism (up to 59%)
- Cerebrovascular Accident (CVA)
- Epilepsy
VIII. Signs
- See Pediatric Seborrheic Dermatitis (Cradle Cap)
- Characteristics
- Distribution
- Common areas
- Scalp
- Nasolabial fold
- Facial involvement (T-distribution)
- Central face
- Beard area
- Eyebrows
- Chest involvement
- Common areas
- Associated skin findings
- Other findings in Skin of Color
- Hypopigmentation patches in eyebrows and nasolabial fold
- Petaloid Seborrhea
- Well-demarcated scaly Plaques affecting the hairline and face
IX. Labs: Biopsy (indicated only in unclear diagnosis)
- Scale crust with Neutrophils (perifollicular)
- Epidermal parakeratosis
- Plugged follicular ostia
- Spongiosis
X. Differential Diagnosis
- Common Scalp conditions
- See Scalp Dermatitis
- Tinea Capitis
- Eczema (Atopic Dermatitis)
- Dry scalp flaking (contrast with oily Seborrhea)
- Contact Dermatitis
- Contact reaction to hair dyes or Shampoos also affects the top of ears and posterior neck
- Psoriasis
- Thick, well-demarcated erythematous Plaques with overlying adherent scale
- Nasolabial fold
- Inverse Psoriasis (smooth Plaques without scale)
- Erythrasma
- Impetigo
- Intertrigo causes
- Irritant dermatitis
- Allergic Contact Dermatitis
- Candidiasis or Dermatophytosis
- External Ear
- Face
- Acne Rosacea
- Inflammatory acne without scale, and central Flushing, Telangiectasia
- Other uncommon causes
- Systemic Lupus Erythematosus
- Secondary Sypilis
- Pediculosis Ciliaris (eyelash lice)
- Langerhans Cell Histiocytosis
- Lichen Simplex Chronicus
- Uremic frost
- Occurs in end-stage renal disease with high BUN (untreated or missed Hemodialysis)
- Crystallized urea from sweat forms and deposits on the skin
- Acne Rosacea
XI. Management: Scalp
- Approach
- General
- Massage the Shampoo into the scalp and leave on for 5 minutes before rinsing
- Start with daily use for several weeks until remission
- Maintain control after remission with use 2 times weekly
- Change to alternative product if one stops working after months of use
- Fungal resistance may develop to a single product
- Mild scalp involvement
- Use over-the-counter Antifungal preparations
- Moderate scalp involvement
- Start with prescription AntifungalShampoo 2-3 times weekly for several weeks until remission
- Maintain control with once weekly use
- Consider medium potency Corticosteroid intermittent, short-term use for itching, inflammation
- Moderate to severe scalp involvement
- High potency Corticosteroid (Clobetasol) twice weekly (wean as inflammation resolves)
- Ketaconazole 2% Shampoo twice weekly
- General
-
Topical Antifungals (Over-The-Counter)
- See application protocol above
- Applied for 5 minutes daily until remission, then twice weekly
- Indications
- First-line therapy in Mild Seborrheic Dermatitis
- First-Line Agents
- Other alternative agents (esp. thick, adherent scalp Scaling)
- See application protocol above
-
Topical Antifungal
Shampoos (prescription)
- See application protocol above
- Applied for 5 minutes daily until remission, then twice weekly
- Ketoconazole 2% (Nizoral) Shampoo
- Ciclopirox 1% Shampoo (Loprox)
- Selenium Sulfide 2.25% Shampoo
- See application protocol above
-
Topical Corticosteroids
- Indications
- Refractory Seborrheic Dermatitis to other topicals (see above)
- Protocol
- Limit to 2 weeks of frequent use (3-7x/week), then taper to occasional use
- Do NOT use high potency Corticosteroids on the face (scalp only)
- Medium potency Topical Corticosteroids (mild to moderate refractory cases)
- Fluocinolone 0.01% Shampoo (e.g. Capex) or solution (e.g. Synalar) applied daily
- Betamethasone valerate 0.12% foam (Luxiq) applied daily to twice daily
- High potency Topical Corticosteroids (moderate to severe refractory cases, use <2 weeks)
- Clobetasol Propionate 0.05% foam or Shampoo (Clobex)
- Mometasone furoate 0.1% solution
- Fluocinonide 0.05% solution
- Betamethasone Dipropionate lotion or foam
- Indications
- Other agents in Seborrheic Dermatitis refractory to all other topical agents
- Oral Antifungals
- Roflumilast 0.3$ foam
- Expensive, Phosphodiesterase-4 Inhibitor applied daily until remission
XII. Management: Face, Ear and Body
- Approach
- Gentle skin care
- Nonsoap cleansers
- Oil-free noncomedogenic, hypoallergenic skin Emollients
- Maintenance: Topical Antifungals
- Topical Antifungals are first-line therapy for face and body Seborrhea
- As effective as Corticosteroids and safe for longterm use
- Inflammation or flare-ups (intermittent and short-term use, ideally for <10-14 days)
- Gentle skin care
-
Topical Antifungals
- Ketoconazole 2% cream (Nizoral), gel (Xolegel) or foam (Extina)
- Twice daily for up to 8 weeks, then as needed
- Most reasonably priced
- Ciclopirox 0.77% gel or 1% cream (Ciclodan, not available in U.S.)
- Twice daily for up to 4 weeks
- Miconazole 2% Cream
- Sertaconazole 2% cream (Ertaczo)
- Twice daily for up to 4 weeks
- Very expensive ($423 for 60 grams in 2014)!
- Ketoconazole 2% cream (Nizoral), gel (Xolegel) or foam (Extina)
-
Topical Corticosteroids (short-term use for flares)
- Low potency Topical Corticosteroids (for facial use)
- Hydrocortisone 1 to 2.5% cream or ointment
- Desonide
- Forms: 0.05% cream, foam (Verdeso), gel (Desonate), lotion (Lokara) or ointment (Desowen)
- Apply once or twice daily
- Medium potency Topical Corticosteroids (limit to use on body; avoid use on face)
- Betamethasone valerate 0.1% cream (Beta-Val) or lotion applied once or twice daily
- Fluocinolone 0.01% cream, oil (Derma Smoothe) or solution (Synalar) applied once to twice daily
- Mometasone 0.1% cream or ointment
- Triamcinolone 0.1% cream or ointment
- Low potency Topical Corticosteroids (for facial use)
- Topical Calcineurin Inhibitors
- Indications
- Seborrheic Dermatitis refractory to topical agents above, or if prolonged Corticosteroid use needed
- See specific medications for precautions
- FDA black box warning for Lymphoma and Skin Cancer risk
- Tacrolimus 0.1% ointment (Protopic)
- Twice daily until remission, then maintenance with twice weekly application
- Pimecrolimus 1% cream (Elidel)
- Twice daily until remission, then maintenance with twice weekly application
- Indications
- Other agents in Seborrheic Dermatitis refractory to all other topical agents
- Metronidazole 0.75% gel
- Sodium sulfacetamide
- Azelaic Acid 15%
- Oral Isotretinoin at low dose
- Roflumilast 0.3$ foam
- Expensive, Phosphodiesterase-4 Inhibitor applied daily until remission
- Oral Antifungals
- Fluconazole 50 mg orally daily for 2 weeks OR
- Fluconazole 200 mg orally weekly for 2 to 4 weeks
XIII. Medications: Anti-inflammatory agents
- Decrease the skin inflammatory response (see pathophysiology above)
-
Topical Corticosteroids
- High potency Topical Corticosteroids (for scalp)
- Clobetasol 0.05% Shampoo (Clobex) twice weekly to scalp
- Medium potency Topical Corticosteroids
- Betamethasone valerate
- Scalp: 0.1% lotion or 0.12% foam applied daily
- Face or body: 0.1% cream (Beta-Val) or lotion applied once or twice daily
- Fluocinolone
- Betamethasone valerate
- Low potency Topical Corticosteroids (for face or body)
- Hydrocortisone 1% cream or ointment
- Desonide 0.05% cream, foam (Verdeso), gel (Desonate), lotion (Lokara) or ointment (Desowen) 1-2x daily
- High potency Topical Corticosteroids (for scalp)
- Topical Calcineurin Inhibitors (for face and body involvement)
- Tacrolimus 0.1% ointment (Protopic)
- Twice daily
- Pimecrolimus 1% cream (Elidel)
- Twice daily
- Tacrolimus 0.1% ointment (Protopic)
XIV. Medications: Keratolytics
- Remove outer layers of the hyperproliferating Stratum Corneum (see pathophysiology above)
- Indicated for scalp or beard area
- Directions
- Apply 2-3 times weekly
- Leave Shampoos applied to scalp for 5 minutes
- Types
XV. Medications: Antifungals
- Suppress the Malassezia Fungus population (see pathophysiology above)
-
Ketoconazole 2%
- Scalp: (Nizoral) Shampoo, starting with daily use, then twice weekly
- Face and body: Cream (Nizoral), gel (Xolegel) or foam (Extina) twice daily for 8 weeks
- Effective for face
- Of the Antifungals, most reasonably priced, and cream is best tolerated
- Ciclopirox
- Sertaconazole 2% cream (Ertaczo)
- Indicated for face and body involvement
- Twice daily for up to 4 weeks
- Very expensive ($423 for 60 grams in 2014)!
- Selenium sulfide 2.5% (Selsun)
- Tea Tree Oil Shampoo (5%)
- Antifungal activity
- Effective and well tolerated
- Satchell (2002) J Am Acad Dermatol 47:852-5 [PubMed]
- Other anti-fungals
- Fluconazole topically
- Oral anti-fungals (Terbinafine) have been used
XVI. Medications: Combination therapies
- Triple cream compounded at pharmacy
- Salicylic acid 2%
- Hydrocortisone 0.05%
- Precipitated Sulfur 3%
- Moderate scalp involvement combination
- Chloroxine 2% Shampoo apply daily
- Flucinolone 0.01% solution apply to scalp daily to twice daily