Definition (CHV)
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a kind of anti-inflammatory drug
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Definition (NCI_NCI-GLOSS)
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A substance that is being studied for the prevention of nonmelanoma skin cancer. It is an anti-inflammatory drug that is applied to the skin to relieve irritation, rashes, and infections. It belongs to the family of drugs called topical corticosteroids.
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Definition (NCI)
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A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B.
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Definition (MSH)
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A glucocorticoid given, as the free alcohol or in esterified form, orally, intramuscularly, by local injection, by inhalation, or applied topically in the management of various disorders in which corticosteroids are indicated. (From Martindale, The Extra Pharmacopoeia, 30th ed, p739)
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Definition (CSP)
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synthetic glucocorticoid used in replacement therapy for adrenal insufficiency and as an anti-inflammatory and immunosuppressant in a variety of disorders.
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Definition (PDQ)
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A synthetic glucocorticoid with anti-inflammatory and immunomodulating properties. Upon cell entry, triamcinolone binds to and activates the glucocorticoid receptor, which leads to translocation of the ligand-receptor complex to the nucleus and induces expression of glucocorticoid-responsive genes such as lipocortins. Lipocortins inhibit phospholipase A2, thereby blocking the release of arachidonic acid from membrane phospholipids and preventing the synthesis of prostaglandins and leukotrienes, both mediators of inflammation. In addition, pro-inflammatory cytokine production, including interleukin (IL)-1and IL-6, and the activation of cytotoxic T-lymphocytes is also inhibited. T-cells are prevented from making IL-2 and proliferating. This agent also decreases the number of circulating lymphocytes, induces cell differentiation, and stimulates apoptosis through increasing Ikappa-B expression and curtailing activation of nuclear factor (NF)kappa-B. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39275&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39275&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C901" NCI Thesaurus)
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Concepts |
Pharmacologic Substance
(T121)
, Steroid
(T110)
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MSH |
D014221
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SnomedCT |
325457006, 116594009, 6028009 |
LNC |
LP35873-6, MTHU018764 |
English |
Triamcinolone, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,16,17,21-tetrahydroxy-, (11beta,16alpha)-, (11beta,16alpha)-9-Fluoro-11,16,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, Triamcinolone [endocrine use], triamcinolone (medication), Triamcinolone [Chemical/Ingredient], Triamcinolone [endocrine use] (product), TRIAMCINOLONE, triamcinolone, Triamcinolone preparation, Triamcinolone (substance), Triamcinolone preparation (product), Triamcinolone [endocrine use] (substance), Triamcinolone preparation (substance) |
Swedish |
Triamcinolon
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Czech |
triamcinolon
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Finnish |
Triamsinoloni
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Russian |
KENAKORT, POL'KORTOLON, TRIAMTSINOLON, КЕНАКОРТ, ПОЛЬКОРТОЛОН, ТРИАМЦИНОЛОН |
Japanese |
トリアムシノロン
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Spanish |
triamcinolona (producto), preparado con triamcinolona (producto), preparado con triamcinolona, triamcinolona (uso endocrino) (producto), triamcinolona (uso endocrino), preparado de triamcinolona (producto), preparado de triamcinolona (sustancia), preparado de triamcinolona, triamcinolona (sustancia), triamcinolona, Triamcinolona |
Polish |
Triamcynolon
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Norwegian |
Triamcinolon
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French |
Triamcinolone
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German |
Triamcinolon
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Italian |
Triamcinolone
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Portuguese |
Triancinolona
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